TY - JOUR
T1 - Circadian rhythms, nutrition and implications for longevity in urban environments
AU - Froy, O.
N1 - Publisher Copyright:
© 2017 The Author.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Presently, about 12% of the population is 65 years or older and by the year 2030 that figure is expected to reach 21%. In order to promote the well-being of the elderly and to reduce the costs associated with health care demands, increased longevity should be accompanied by ageing attenuation. Energy restriction, which limits the amount of energy consumed to 60-70% of the daily intake, and intermittent fasting, which allows the food to be available ad libitum every other day, extend the life span of mammals and prevent or delay the onset of major age-related diseases, such as cancer, diabetes and cataracts. Recently, we have shown that well-being can be achieved by resetting of the circadian clock and induction of robust catabolic circadian rhythms via timed feeding. In addition, the clock mechanism regulates metabolism and major metabolic proteins are key factors in the core clock mechanism. Therefore, it is necessary to increase our understanding of circadian regulation over metabolism and longevity and to design new therapies based on this regulation. This review will explore the present data in the field of circadian rhythms, ageing and metabolism.
AB - Presently, about 12% of the population is 65 years or older and by the year 2030 that figure is expected to reach 21%. In order to promote the well-being of the elderly and to reduce the costs associated with health care demands, increased longevity should be accompanied by ageing attenuation. Energy restriction, which limits the amount of energy consumed to 60-70% of the daily intake, and intermittent fasting, which allows the food to be available ad libitum every other day, extend the life span of mammals and prevent or delay the onset of major age-related diseases, such as cancer, diabetes and cataracts. Recently, we have shown that well-being can be achieved by resetting of the circadian clock and induction of robust catabolic circadian rhythms via timed feeding. In addition, the clock mechanism regulates metabolism and major metabolic proteins are key factors in the core clock mechanism. Therefore, it is necessary to increase our understanding of circadian regulation over metabolism and longevity and to design new therapies based on this regulation. This review will explore the present data in the field of circadian rhythms, ageing and metabolism.
KW - Circadian rhythms
KW - Clock
KW - Feeding
KW - Life span
KW - Metabolism
KW - Nutrition
UR - http://www.scopus.com/inward/record.url?scp=85033373290&partnerID=8YFLogxK
U2 - 10.1017/S0029665117003962
DO - 10.1017/S0029665117003962
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C2 - 29065948
AN - SCOPUS:85033373290
SN - 0029-6651
VL - 77
SP - 216
EP - 222
JO - Proceedings of the Nutrition Society
JF - Proceedings of the Nutrition Society
IS - 3
ER -