Circuit formation and maintenance-perspectives from the mammalian olfactory bulb

Yoav Adam*, Adi Mizrahi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


The rodent olfactory bulb (OB) is becoming a model system for studying how neuronal circuits develop and maintain. The OB has typical components of a sensory circuit such as ordered sensory inputs, diverse populations of interneurons, substantial neuromodulatory innervation, and projection neurons that transfer information to higher brain centers. Additionally, the OB is unique because its sensory afferents and a subset of its interneurons are continuously replaced throughout adulthood. Here, we review some recent findings on the development and maintenance of the mammalian OB circuitry. We review some of the known developmental strategies of the major OB components and discuss the ways in which the OB circuitry preserves stability in the face of ongoing changes.

Original languageAmerican English
Pages (from-to)134-140
Number of pages7
JournalCurrent Opinion in Neurobiology
Issue number1
StatePublished - Feb 2010

Bibliographical note

Funding Information:
We thank S. Wagner, and Y. Livneh for discussions and the rest of the Mizrahi lab for critically commenting on early versions of this manuscript. This work is supported by The Human Frontier Science Program (grant number RGP0029/07 ) and by the European Research Council (grant number 203994 ) to A.M.


Dive into the research topics of 'Circuit formation and maintenance-perspectives from the mammalian olfactory bulb'. Together they form a unique fingerprint.

Cite this