Abstract
The rodent olfactory bulb (OB) is becoming a model system for studying how neuronal circuits develop and maintain. The OB has typical components of a sensory circuit such as ordered sensory inputs, diverse populations of interneurons, substantial neuromodulatory innervation, and projection neurons that transfer information to higher brain centers. Additionally, the OB is unique because its sensory afferents and a subset of its interneurons are continuously replaced throughout adulthood. Here, we review some recent findings on the development and maintenance of the mammalian OB circuitry. We review some of the known developmental strategies of the major OB components and discuss the ways in which the OB circuitry preserves stability in the face of ongoing changes.
| Original language | English |
|---|---|
| Pages (from-to) | 134-140 |
| Number of pages | 7 |
| Journal | Current Opinion in Neurobiology |
| Volume | 20 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2010 |
Bibliographical note
Funding Information:We thank S. Wagner, and Y. Livneh for discussions and the rest of the Mizrahi lab for critically commenting on early versions of this manuscript. This work is supported by The Human Frontier Science Program (grant number RGP0029/07 ) and by the European Research Council (grant number 203994 ) to A.M.