Circulating Estrogen Levels and Self-Reported Health and Mobility Limitation in Community-Dwelling Men of the Framingham Heart Study

Guneet Kaur Jasuja, Thomas G. Travison, Joanne M. Murabito, Maithili N. Davda, Adam J. Rose, Shehzad Basaria, Andrea Coviello, Ramachandran S. Vasan, Ralph D'Agostino, Shalender Bhasin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Self-rated health is a commonly used global indicator of health status. Few studies have examined the association of self-rated health and mobility with estrone and estradiol in men. Accordingly, we determined the cross-sectional, incident, and mediating relations between circulating estrone and estradiol levels with self-rated health, mobility limitation, and physical performance in community-dwelling men. Methods: The cross-sectional sample included 1,148 men, who attended Framingham Offspring Study Examinations 7 and 8. Estrone and estradiol levels were measured using liquid chromatography tandem mass spectrometry at Examination 7. Self-reported mobility limitation and self-rated health were assessed at Examinations 7 and 8. Additionally, short physical performance battery, usual walking speed, and grip strength were assessed at Examination 7. Results: In incident analysis, estradiol levels at Examination 7 were associated with increased odds of fair or poor self-rated health at Examination 8, after adjusting for age, body mass index, comorbidities, and testosterone levels; in an individual with 50% greater estradiol than other, the odds of reporting "fair or poor" self-rated health increased by 1.78 (95% confidence interval: 1.25-2.55; p = .001). Neither estrone nor estradiol levels were associated with any physical performance measure at baseline. Conclusions: Higher circulating levels of estradiol are associated with increased risk of incident fair/poor self-rated health in communitydwelling men. The mechanisms by which circulating levels of estradiol are related to self-rated health in men need further investigation.

Original languageAmerican English
Pages (from-to)1137-1142
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number8
StatePublished - 1 Aug 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.


  • Estradiol
  • Estrone
  • Physical function
  • Self-rated health


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