Background: Self-rated health is a commonly used global indicator of health status. Few studies have examined the association of self-rated health and mobility with estrone and estradiol in men. Accordingly, we determined the cross-sectional, incident, and mediating relations between circulating estrone and estradiol levels with self-rated health, mobility limitation, and physical performance in community-dwelling men. Methods: The cross-sectional sample included 1,148 men, who attended Framingham Offspring Study Examinations 7 and 8. Estrone and estradiol levels were measured using liquid chromatography tandem mass spectrometry at Examination 7. Self-reported mobility limitation and self-rated health were assessed at Examinations 7 and 8. Additionally, short physical performance battery, usual walking speed, and grip strength were assessed at Examination 7. Results: In incident analysis, estradiol levels at Examination 7 were associated with increased odds of fair or poor self-rated health at Examination 8, after adjusting for age, body mass index, comorbidities, and testosterone levels; in an individual with 50% greater estradiol than other, the odds of reporting "fair or poor" self-rated health increased by 1.78 (95% confidence interval: 1.25-2.55; p = .001). Neither estrone nor estradiol levels were associated with any physical performance measure at baseline. Conclusions: Higher circulating levels of estradiol are associated with increased risk of incident fair/poor self-rated health in communitydwelling men. The mechanisms by which circulating levels of estradiol are related to self-rated health in men need further investigation.
|Original language||American English|
|Number of pages||6|
|Journal||Journals of Gerontology - Series A Biological Sciences and Medical Sciences|
|State||Published - 1 Aug 2017|
Bibliographical noteFunding Information:
This work was supported by the National Institutes of Health grant 1R01DK092938 (to S.B.) and the Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies (5P30AG0136).
© The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.
- Physical function
- Self-rated health