TY - JOUR
T1 - Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa
AU - the Ghana Breast Health Study Team
AU - Ahuno, Samuel Terkper
AU - Doebley, Anna Lisa
AU - Ahearn, Thomas U.
AU - Yarney, Joel
AU - Titiloye, Nicholas
AU - Hamel, Nancy
AU - Adjei, Ernest
AU - Clegg-Lamptey, Joe Nat
AU - Edusei, Lawrence
AU - Awuah, Baffour
AU - Song, Xiaoyu
AU - Vanderpuye, Verna
AU - Abubakar, Mustapha
AU - Duggan, Maire
AU - Stover, Daniel G.
AU - Nyarko, Kofi
AU - Bartlett, John M.S.
AU - Aitpillah, Francis
AU - Ansong, Daniel
AU - Gardner, Kevin L.
AU - Boateng, Felix Andy
AU - Bowcock, Anne M.
AU - Caldas, Carlos
AU - Foulkes, William D.
AU - Wiafe, Seth
AU - Wiafe-Addai, Beatrice
AU - Garcia-Closas, Montserrat
AU - Kwarteng, Alexander
AU - Ha, Gavin
AU - Figueroa, Jonine D.
AU - Polak, Paz
AU - Adjei, Robertson
AU - Afriyie, Lucy
AU - Adjei, Anthony
AU - Dedey, Florence
AU - Okyne, Victoria
AU - Oti, Naomi Ohene
AU - Tay, Evelyn
AU - Adu-Aryee,
AU - Kenu, Angela
AU - Ekpedzor, Obed
AU - Alcpaloo, Marion
AU - Boakye, Isaac
AU - Arhin, Bernard
AU - Assimah, Emmanuel
AU - Ka-Chungu, Samuel
AU - Oppong, Joseph
AU - Osei-Bonsu, Ernest
AU - Frempong, Margaret
AU - Abaidoo, Emma Brew
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients.
AB - Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients.
UR - https://www.scopus.com/pages/publications/85116954878
U2 - 10.1038/s41698-021-00219-7
DO - 10.1038/s41698-021-00219-7
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AN - SCOPUS:85116954878
SN - 2397-768X
VL - 5
JO - npj Precision Oncology
JF - npj Precision Oncology
IS - 1
M1 - 83
ER -
SDG 3 Good Health and Well-being