Clarithromycin as the empiric antibiotic therapy for medication-related osteonecrosis of the jaw in multiple myeloma patients

Yehuda Zadik

doi:10.1016/j.oraloncology.2018.07.016

Clarithromycin as the empiric antibiotic therapy for medication-related osteonecrosis of the jaw in multiple myeloma patients

Yehuda Zadik^*

^*Corresponding author for this work

ZAMERET

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

About half of individuals diagnosed with medication-related osteonecrosis of the jaw (MRONJ) are multiple myeloma (MM) patients, and most are treated using antibiotics for long-term courses. The penicillin group is recommended as the empiric drug of choice, and quinolones, metronidazole, clindamycin, doxycycline, and erythromycin as alternatives. This paper suggests the macrolide clarithromycin as the empiric antibiotic therapy of MRONJ in MM patients because of its better pharmacologic properties in comparison to erythromycin, and the beneficial effect of this agent in MM. This empiric antibiotic regimen should be later adjusted according to the response and findings of the microbial cultures.

Original language	American English
Pages (from-to)	104-105
Number of pages	2
Journal	Oral Oncology
Volume	84
DOIs	https://doi.org/10.1016/j.oraloncology.2018.07.016
State	Published - Sep 2018

Bibliographical note

Publisher Copyright:
© 2018

Keywords

Antibiotics
Antimicrobial agents
Bisphosphonate
Macrolides
Oral medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.oraloncology.2018.07.016

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title = "Clarithromycin as the empiric antibiotic therapy for medication-related osteonecrosis of the jaw in multiple myeloma patients",

abstract = "About half of individuals diagnosed with medication-related osteonecrosis of the jaw (MRONJ) are multiple myeloma (MM) patients, and most are treated using antibiotics for long-term courses. The penicillin group is recommended as the empiric drug of choice, and quinolones, metronidazole, clindamycin, doxycycline, and erythromycin as alternatives. This paper suggests the macrolide clarithromycin as the empiric antibiotic therapy of MRONJ in MM patients because of its better pharmacologic properties in comparison to erythromycin, and the beneficial effect of this agent in MM. This empiric antibiotic regimen should be later adjusted according to the response and findings of the microbial cultures.",

keywords = "Antibiotics, Antimicrobial agents, Bisphosphonate, Macrolides, Oral medicine",

author = "Yehuda Zadik",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = sep,

doi = "10.1016/j.oraloncology.2018.07.016",

language = "American English",

volume = "84",

pages = "104--105",

journal = "Oral Oncology",

issn = "1368-8375",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - Clarithromycin as the empiric antibiotic therapy for medication-related osteonecrosis of the jaw in multiple myeloma patients

AU - Zadik, Yehuda

PY - 2018/9

Y1 - 2018/9

N2 - About half of individuals diagnosed with medication-related osteonecrosis of the jaw (MRONJ) are multiple myeloma (MM) patients, and most are treated using antibiotics for long-term courses. The penicillin group is recommended as the empiric drug of choice, and quinolones, metronidazole, clindamycin, doxycycline, and erythromycin as alternatives. This paper suggests the macrolide clarithromycin as the empiric antibiotic therapy of MRONJ in MM patients because of its better pharmacologic properties in comparison to erythromycin, and the beneficial effect of this agent in MM. This empiric antibiotic regimen should be later adjusted according to the response and findings of the microbial cultures.

AB - About half of individuals diagnosed with medication-related osteonecrosis of the jaw (MRONJ) are multiple myeloma (MM) patients, and most are treated using antibiotics for long-term courses. The penicillin group is recommended as the empiric drug of choice, and quinolones, metronidazole, clindamycin, doxycycline, and erythromycin as alternatives. This paper suggests the macrolide clarithromycin as the empiric antibiotic therapy of MRONJ in MM patients because of its better pharmacologic properties in comparison to erythromycin, and the beneficial effect of this agent in MM. This empiric antibiotic regimen should be later adjusted according to the response and findings of the microbial cultures.

KW - Antibiotics

KW - Antimicrobial agents

KW - Bisphosphonate

KW - Macrolides

KW - Oral medicine

UR - http://www.scopus.com/inward/record.url?scp=85050516989&partnerID=8YFLogxK

U2 - 10.1016/j.oraloncology.2018.07.016

DO - 10.1016/j.oraloncology.2018.07.016

M3 - Short survey

C2 - 30115467

AN - SCOPUS:85050516989

SN - 1368-8375

VL - 84

SP - 104

EP - 105

JO - Oral Oncology

JF - Oral Oncology

ER -

Clarithromycin as the empiric antibiotic therapy for medication-related osteonecrosis of the jaw in multiple myeloma patients

Abstract

Bibliographical note

Keywords

UN SDGs

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