TY - JOUR
T1 - Clarithromycin as the empiric antibiotic therapy for medication-related osteonecrosis of the jaw in multiple myeloma patients
AU - Zadik, Yehuda
N1 - Publisher Copyright:
© 2018
PY - 2018/9
Y1 - 2018/9
N2 - About half of individuals diagnosed with medication-related osteonecrosis of the jaw (MRONJ) are multiple myeloma (MM) patients, and most are treated using antibiotics for long-term courses. The penicillin group is recommended as the empiric drug of choice, and quinolones, metronidazole, clindamycin, doxycycline, and erythromycin as alternatives. This paper suggests the macrolide clarithromycin as the empiric antibiotic therapy of MRONJ in MM patients because of its better pharmacologic properties in comparison to erythromycin, and the beneficial effect of this agent in MM. This empiric antibiotic regimen should be later adjusted according to the response and findings of the microbial cultures.
AB - About half of individuals diagnosed with medication-related osteonecrosis of the jaw (MRONJ) are multiple myeloma (MM) patients, and most are treated using antibiotics for long-term courses. The penicillin group is recommended as the empiric drug of choice, and quinolones, metronidazole, clindamycin, doxycycline, and erythromycin as alternatives. This paper suggests the macrolide clarithromycin as the empiric antibiotic therapy of MRONJ in MM patients because of its better pharmacologic properties in comparison to erythromycin, and the beneficial effect of this agent in MM. This empiric antibiotic regimen should be later adjusted according to the response and findings of the microbial cultures.
KW - Antibiotics
KW - Antimicrobial agents
KW - Bisphosphonate
KW - Macrolides
KW - Oral medicine
UR - http://www.scopus.com/inward/record.url?scp=85050516989&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2018.07.016
DO - 10.1016/j.oraloncology.2018.07.016
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C2 - 30115467
AN - SCOPUS:85050516989
SN - 1368-8375
VL - 84
SP - 104
EP - 105
JO - Oral Oncology
JF - Oral Oncology
ER -