Claustral Neurons Projecting to Frontal Cortex Mediate Contextual Association of Reward

Anna Terem, Ben Jerry Gonzales, Noa Peretz-Rivlin, Reut Ashwal-Fluss, Noa Bleistein, Maria del Mar Reus-Garcia, Diptendu Mukherjee, Maya Groysman, Ami Citri*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Terem et al. uncover the role of the claustrum in context reinforcement. They identify claustral dopamine D1-receptor-expressing neurons as a subpopulation of frontal-projecting claustral neurons important for de novo context reinforcement and the acquisition of cocaine preference.

Original languageAmerican English
Pages (from-to)3522-3532.e6
JournalCurrent Biology
Issue number18
StatePublished - 21 Sep 2020

Bibliographical note

Funding Information:
The authors appreciate the helpful critical comments of Drs. Inbal Goshen, Segev Barak, Mickey London, Adi Mizrahi, and Eran Lottem, as well as 4 anonymous reviewers, on data, writing, and presentation. We are indebted to Dr. Naomi Book-Melamed, head of the microscopy unit at the Life Science Institute, for technical support in establishing the imaging system required for efficient acquisition of multiplexed smFISH signals. Work in the A.C.’s laboratory is funded by the European Research Council ( ERC 770951 ), The Israel Science Foundation ( 1062/18 , 393/12 , 1796/12 , and 2341/15 ), The Israel Anti-Drug Administration , EU Marie Curie ( PCIG13-GA-2013-618201 ), the National Institute for Psychobiology in Israel, Hebrew University of Jerusalem Israel founded by the Charles E. Smith family ( 109-15-16 ), an Adelis Award for Advances in Neuroscience , the Brain and Behavior Foundation ( NARSAD 18795 ), German–Israel Foundation ( 2299-2291.1/2011 ), and Binational Israel–United States Foundation ( 2011266 ), a seed grant from the Eric Roland Fund for interdisciplinary research administered by the ELSC, contributions from anonymous philanthropists in Los Angeles and Mexico City, as well as research support from the Safra Center for Brain Sciences (ELSC) and the Canadian Institute for Advanced Research (CIFAR).

Publisher Copyright:
© 2020 The Author(s)


  • Drd1
  • claustrum
  • cocaine
  • conditioned-place preference
  • frontal cortex
  • incentive salience
  • real-time conditioned-place preference
  • reward


Dive into the research topics of 'Claustral Neurons Projecting to Frontal Cortex Mediate Contextual Association of Reward'. Together they form a unique fingerprint.

Cite this