Claustrum neurons projecting to the anterior cingulate restrict engagement during sleep and behavior

Gal Atlan, Noa Matosevich, Noa Peretz-Rivlin, Idit Marsh-Yvgi, Noam Zelinger, Eden Chen, Timna Kleinman, Noa Bleistein, Efrat Sheinbach, Maya Groysman, Yuval Nir, Ami Citri*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The claustrum has been linked to attention and sleep. We hypothesized that this reflects a shared function, determining responsiveness to stimuli, which spans the axis of engagement. To test this hypothesis, we recorded claustrum population dynamics from male mice during both sleep and an attentional task (‘ENGAGE’). Heightened activity in claustrum neurons projecting to the anterior cingulate cortex (ACCp) corresponded to reduced sensory responsiveness during sleep. Similarly, in the ENGAGE task, heightened ACCp activity correlated with disengagement and behavioral lapses, while low ACCp activity correlated with hyper-engagement and impulsive errors. Chemogenetic elevation of ACCp activity reduced both awakenings during sleep and impulsive errors in the ENGAGE task. Furthermore, mice employing an exploration strategy in the task showed a stronger correlation between ACCp activity and performance compared to mice employing an exploitation strategy which reduced task complexity. Our results implicate ACCp claustrum neurons in restricting engagement during sleep and goal-directed behavior.

Original languageEnglish
Article number5415
JournalNature Communications
Volume15
Issue number1
DOIs
StatePublished - Dec 2024

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© The Author(s) 2024.

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