TY - JOUR
T1 - Climbing Neuronal Activity as an Event-Based Cortical Representation of Time
AU - Reutimann, Jan
AU - Yakovlev, Volodya
AU - Fusi, Stefano
AU - Senn, Walter
PY - 2004/3/31
Y1 - 2004/3/31
N2 - The brain has the ability to represent the passage of time between two behaviorally relevant events. Recordings from different areas in the cortex of monkeys suggest the existence of neurons representing time by increasing (climbing) activity, which is triggered by a first event and peaks at the expected time of a second event, e.g., a visual stimulus or a reward. When the typical interval between the two events is changed, the slope of the climbing activity adapts to the new timing. We present a model in which the climbing activity results from slow firing rate adaptation in inhibitory neurons. Hebbian synaptic modifications allow for learning the new time interval by changing the degree of firing rate adaptation. This event-based representation of time is consistent with Weber's law in interval timing, according to which the error in estimating a time interval is proportional to the interval length.
AB - The brain has the ability to represent the passage of time between two behaviorally relevant events. Recordings from different areas in the cortex of monkeys suggest the existence of neurons representing time by increasing (climbing) activity, which is triggered by a first event and peaks at the expected time of a second event, e.g., a visual stimulus or a reward. When the typical interval between the two events is changed, the slope of the climbing activity adapts to the new timing. We present a model in which the climbing activity results from slow firing rate adaptation in inhibitory neurons. Hebbian synaptic modifications allow for learning the new time interval by changing the degree of firing rate adaptation. This event-based representation of time is consistent with Weber's law in interval timing, according to which the error in estimating a time interval is proportional to the interval length.
KW - Delay activity
KW - Firing rate adaptation
KW - Hebbian synaptic plasticity
KW - Learning cellular timers
KW - Neuronal clock
KW - Weber law in interval timing
UR - http://www.scopus.com/inward/record.url?scp=1842578358&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.4098-03.2004
DO - 10.1523/JNEUROSCI.4098-03.2004
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C2 - 15056709
AN - SCOPUS:1842578358
SN - 0270-6474
VL - 24
SP - 3295
EP - 3303
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 13
ER -