Clinical characteristics and outcome of infective endocarditis due to Abiotrophia and Granulicatella compared to Viridans group streptococci

International Collaboration on Endocarditis (ICE) Investigators

doi:10.1016/j.jinf.2022.05.023

Clinical characteristics and outcome of infective endocarditis due to Abiotrophia and Granulicatella compared to Viridans group streptococci

International Collaboration on Endocarditis (ICE) Investigators

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Objective: To describe the clinical characteristics and outcome of Abiotrophia and Granulicatella infective endocarditis and compare them with Viridans group streptococci infective endocarditis. Methods: All patients in the International Collaboration on Endocarditis (ICE) - prospective cohort study (PCS) and the ICE-PLUS cohort were included (n = 8112). Data from patients with definitive or possible IE due to Abiotrophia species, Granulicatella species and Viridans group streptococci was analyzed. A propensity score (PS) analysis comparing the ABI/GRA-IE and VGS-IE groups according to a 1:2 ratio was performed. Results: Forty-eight (0.64%) cases of ABI/GRA-IE and 1,292 (17.2%) VGS-IE were included in the analysis. The median age of patients with ABI/GRA-IE was lower than VGS-IE (48.1 years vs. 57.9 years; p = 0.001). Clinical features and the rate of in-hospital surgery was similar between ABI/GRA-IE and VGS-IE (52.1% vs. 45.4%; p = 0.366). Unadjusted in-hospital death was lower in ABI/GRA-IE than VGS-IE (2.1% vs. 8.8%; p = 0.003), and cumulative six-month mortality was lower in ABI/GRA-IE than VGS-IE (2.1% vs. 11.9%; p<0.001). After PS analysis, in-hospital mortality was similar in both groups, but six-month mortality was lower in the ABI/GRA IE group (2.1% vs. 10.4%; p = 0.029). Conclusions: Patients with ABI/GRA-IE were younger, had similar clinical features and rates of surgery and better prognosis than VGS-IE.

Original language	American English
Pages (from-to)	137-146
Number of pages	10
Journal	Journal of Infection
Volume	85
Issue number	2
DOIs	https://doi.org/10.1016/j.jinf.2022.05.023
State	Published - Aug 2022

Bibliographical note

Funding Information:
This work was supported by the Resident Award “Emili Letang”, granted by Hospital Clínic de Barcelona, Research, Innovation and Education Department to AT. JMM received a personal 80:20 research grant from the Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, during 2017–23.

Funding Information:
JMM has received consulting honoraria and/or research grants from AbbVie, Bristol-Myers Squibb, Contrafect, Genentech, Jansen, Medtronic, MSD, Novartis, Gilead Sciences, and ViiV Healthcare, outside the submitted work. CWW is a founder of Predigen Inc, and has received honoraria and/or research grants from Roche Molecular Sciences, Biomerieux, Biofire, Giner, IDbyDNA, Janssen, and Sanofi, outside the submitted work. VHC has received consulting honoraria from UpToDate and Theravance, outside of the submitted work. All other authors: no conflicts.

Publisher Copyright:
© 2022 The British Infection Association

Keywords

Abiotrophia, Granulicatella
Infective endocarditis
International collaboration on endocarditis
Viridans group streptococci
Abiotrophia Granulicatella

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jinf.2022.05.023

Cite this

@article{2ca1071fcada4af989044b8e352396ac,

title = "Clinical characteristics and outcome of infective endocarditis due to Abiotrophia and Granulicatella compared to Viridans group streptococci",

abstract = "Objective: To describe the clinical characteristics and outcome of Abiotrophia and Granulicatella infective endocarditis and compare them with Viridans group streptococci infective endocarditis. Methods: All patients in the International Collaboration on Endocarditis (ICE) - prospective cohort study (PCS) and the ICE-PLUS cohort were included (n = 8112). Data from patients with definitive or possible IE due to Abiotrophia species, Granulicatella species and Viridans group streptococci was analyzed. A propensity score (PS) analysis comparing the ABI/GRA-IE and VGS-IE groups according to a 1:2 ratio was performed. Results: Forty-eight (0.64%) cases of ABI/GRA-IE and 1,292 (17.2%) VGS-IE were included in the analysis. The median age of patients with ABI/GRA-IE was lower than VGS-IE (48.1 years vs. 57.9 years; p = 0.001). Clinical features and the rate of in-hospital surgery was similar between ABI/GRA-IE and VGS-IE (52.1% vs. 45.4%; p = 0.366). Unadjusted in-hospital death was lower in ABI/GRA-IE than VGS-IE (2.1% vs. 8.8%; p = 0.003), and cumulative six-month mortality was lower in ABI/GRA-IE than VGS-IE (2.1% vs. 11.9%; p<0.001). After PS analysis, in-hospital mortality was similar in both groups, but six-month mortality was lower in the ABI/GRA IE group (2.1% vs. 10.4%; p = 0.029). Conclusions: Patients with ABI/GRA-IE were younger, had similar clinical features and rates of surgery and better prognosis than VGS-IE.",

keywords = "Abiotrophia, Granulicatella, Infective endocarditis, International collaboration on endocarditis, Viridans group streptococci, Abiotrophia Granulicatella",

author = "{International Collaboration on Endocarditis (ICE) Investigators} and Adri{\'a}n T{\'e}llez and Juan Ambrosioni and Marta Hern{\'a}ndez-Meneses and Jaume Llopis and Marco Ripa and Chambers, {Stephen T.} and David Holland and Manel Almela and N{\'u}ria Fern{\'a}ndez-Hidalgo and Benito Almirante and Emilio Bouza and Jacob Strahilevitz and Hannan, {Margaret M.} and John Harkness and Kanafani, {Zeina A.} and Tahaniyat Lalani and Selwyn Lang and Nigel Raymond and Kerry Read and Tatiana Vinogradova and Woods, {Christopher W.} and Dannah Wray and Asuncion Moreno and Chu, {Vivian H.} and Miro, {Jose M.}",

note = "Funding Information: This work was supported by the Resident Award “Emili Letang”, granted by Hospital Cl{\'i}nic de Barcelona, Research, Innovation and Education Department to AT. JMM received a personal 80:20 research grant from the Institut d'Investigacions Biom{\`e}diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, during 2017–23. Funding Information: JMM has received consulting honoraria and/or research grants from AbbVie, Bristol-Myers Squibb, Contrafect, Genentech, Jansen, Medtronic, MSD, Novartis, Gilead Sciences, and ViiV Healthcare, outside the submitted work. CWW is a founder of Predigen Inc, and has received honoraria and/or research grants from Roche Molecular Sciences, Biomerieux, Biofire, Giner, IDbyDNA, Janssen, and Sanofi, outside the submitted work. VHC has received consulting honoraria from UpToDate and Theravance, outside of the submitted work. All other authors: no conflicts. Publisher Copyright: {\textcopyright} 2022 The British Infection Association",

year = "2022",

month = aug,

doi = "10.1016/j.jinf.2022.05.023",

language = "American English",

volume = "85",

pages = "137--146",

journal = "Journal of Infection",

issn = "0163-4453",

publisher = "W.B. Saunders Ltd",

number = "2",

}

TY - JOUR

T1 - Clinical characteristics and outcome of infective endocarditis due to Abiotrophia and Granulicatella compared to Viridans group streptococci

AU - International Collaboration on Endocarditis (ICE) Investigators

AU - Téllez, Adrián

AU - Ambrosioni, Juan

AU - Hernández-Meneses, Marta

AU - Llopis, Jaume

AU - Ripa, Marco

AU - Chambers, Stephen T.

AU - Holland, David

AU - Almela, Manel

AU - Fernández-Hidalgo, Núria

AU - Almirante, Benito

AU - Bouza, Emilio

AU - Strahilevitz, Jacob

AU - Hannan, Margaret M.

AU - Harkness, John

AU - Kanafani, Zeina A.

AU - Lalani, Tahaniyat

AU - Lang, Selwyn

AU - Raymond, Nigel

AU - Read, Kerry

AU - Vinogradova, Tatiana

AU - Woods, Christopher W.

AU - Wray, Dannah

AU - Moreno, Asuncion

AU - Chu, Vivian H.

AU - Miro, Jose M.

N1 - Funding Information: This work was supported by the Resident Award “Emili Letang”, granted by Hospital Clínic de Barcelona, Research, Innovation and Education Department to AT. JMM received a personal 80:20 research grant from the Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, during 2017–23. Funding Information: JMM has received consulting honoraria and/or research grants from AbbVie, Bristol-Myers Squibb, Contrafect, Genentech, Jansen, Medtronic, MSD, Novartis, Gilead Sciences, and ViiV Healthcare, outside the submitted work. CWW is a founder of Predigen Inc, and has received honoraria and/or research grants from Roche Molecular Sciences, Biomerieux, Biofire, Giner, IDbyDNA, Janssen, and Sanofi, outside the submitted work. VHC has received consulting honoraria from UpToDate and Theravance, outside of the submitted work. All other authors: no conflicts. Publisher Copyright: © 2022 The British Infection Association

PY - 2022/8

Y1 - 2022/8

N2 - Objective: To describe the clinical characteristics and outcome of Abiotrophia and Granulicatella infective endocarditis and compare them with Viridans group streptococci infective endocarditis. Methods: All patients in the International Collaboration on Endocarditis (ICE) - prospective cohort study (PCS) and the ICE-PLUS cohort were included (n = 8112). Data from patients with definitive or possible IE due to Abiotrophia species, Granulicatella species and Viridans group streptococci was analyzed. A propensity score (PS) analysis comparing the ABI/GRA-IE and VGS-IE groups according to a 1:2 ratio was performed. Results: Forty-eight (0.64%) cases of ABI/GRA-IE and 1,292 (17.2%) VGS-IE were included in the analysis. The median age of patients with ABI/GRA-IE was lower than VGS-IE (48.1 years vs. 57.9 years; p = 0.001). Clinical features and the rate of in-hospital surgery was similar between ABI/GRA-IE and VGS-IE (52.1% vs. 45.4%; p = 0.366). Unadjusted in-hospital death was lower in ABI/GRA-IE than VGS-IE (2.1% vs. 8.8%; p = 0.003), and cumulative six-month mortality was lower in ABI/GRA-IE than VGS-IE (2.1% vs. 11.9%; p<0.001). After PS analysis, in-hospital mortality was similar in both groups, but six-month mortality was lower in the ABI/GRA IE group (2.1% vs. 10.4%; p = 0.029). Conclusions: Patients with ABI/GRA-IE were younger, had similar clinical features and rates of surgery and better prognosis than VGS-IE.

AB - Objective: To describe the clinical characteristics and outcome of Abiotrophia and Granulicatella infective endocarditis and compare them with Viridans group streptococci infective endocarditis. Methods: All patients in the International Collaboration on Endocarditis (ICE) - prospective cohort study (PCS) and the ICE-PLUS cohort were included (n = 8112). Data from patients with definitive or possible IE due to Abiotrophia species, Granulicatella species and Viridans group streptococci was analyzed. A propensity score (PS) analysis comparing the ABI/GRA-IE and VGS-IE groups according to a 1:2 ratio was performed. Results: Forty-eight (0.64%) cases of ABI/GRA-IE and 1,292 (17.2%) VGS-IE were included in the analysis. The median age of patients with ABI/GRA-IE was lower than VGS-IE (48.1 years vs. 57.9 years; p = 0.001). Clinical features and the rate of in-hospital surgery was similar between ABI/GRA-IE and VGS-IE (52.1% vs. 45.4%; p = 0.366). Unadjusted in-hospital death was lower in ABI/GRA-IE than VGS-IE (2.1% vs. 8.8%; p = 0.003), and cumulative six-month mortality was lower in ABI/GRA-IE than VGS-IE (2.1% vs. 11.9%; p<0.001). After PS analysis, in-hospital mortality was similar in both groups, but six-month mortality was lower in the ABI/GRA IE group (2.1% vs. 10.4%; p = 0.029). Conclusions: Patients with ABI/GRA-IE were younger, had similar clinical features and rates of surgery and better prognosis than VGS-IE.

KW - Abiotrophia, Granulicatella

KW - Infective endocarditis

KW - International collaboration on endocarditis

KW - Viridans group streptococci

KW - Abiotrophia Granulicatella

UR - http://www.scopus.com/inward/record.url?scp=85132748229&partnerID=8YFLogxK

U2 - 10.1016/j.jinf.2022.05.023

DO - 10.1016/j.jinf.2022.05.023

M3 - Article

C2 - 35618152

AN - SCOPUS:85132748229

SN - 0163-4453

VL - 85

SP - 137

EP - 146

JO - Journal of Infection

JF - Journal of Infection

IS - 2

ER -

Clinical characteristics and outcome of infective endocarditis due to Abiotrophia and Granulicatella compared to Viridans group streptococci

Abstract

Bibliographical note

Keywords

UN SDGs

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