TY - JOUR
T1 - Clinical outcome of planned oocyte cryopreservation at advanced age
AU - Tsafrir, Avi
AU - Ben-Ami, Ido
AU - Eldar-Geva, Talia
AU - Gal, Michael
AU - Dekel, Nava
AU - Levi, Hadassah
AU - Schonberger, Oshrat
AU - Srebnik, Naama
AU - Weintraub, Amir
AU - Goldberg, Doron
AU - Hyman, Jordana
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/11
Y1 - 2022/11
N2 - Purpose: To report outcome of planned oocyte cryopreservation (POC) in the first 8 years of this treatment in our center. Methods: A retrospective study in a university-affiliated medical center. Results: A total of 446 women underwent POC during 2011–2018. Fifty-seven (13%) women presented to use these oocytes during the study period (until June 2021). POC was performed at a mean age of 37.9 ± 2.0 (range 33–41). Age at thawing was 43.3 ± 2.1 (range 38–49). A total of 34 (60%) women transferred their oocytes for thawing at other units. Oocyte survival after thawing was significantly higher at our center than following shipping to ancillary sites (78 vs. 63%, p = 0.047). Forty-nine women completed their treatment, either depleting their cryopreserved oocytes without conceiving (36) or attaining a live birth (13)—27% live birth rate per woman. Only one of eleven women who cryopreserved oocytes aged 40 and older had a live birth using thawed oocytes. Conclusion: Women should be advised to complete planned oocyte cryopreservation before age 40, given low success rates in women who underwent cryopreservation at advanced reproductive age. In this study, oocyte shipping was associated with lower survival rate. These findings may be relevant for women considering POC and utilization of cryopreserved oocytes.
AB - Purpose: To report outcome of planned oocyte cryopreservation (POC) in the first 8 years of this treatment in our center. Methods: A retrospective study in a university-affiliated medical center. Results: A total of 446 women underwent POC during 2011–2018. Fifty-seven (13%) women presented to use these oocytes during the study period (until June 2021). POC was performed at a mean age of 37.9 ± 2.0 (range 33–41). Age at thawing was 43.3 ± 2.1 (range 38–49). A total of 34 (60%) women transferred their oocytes for thawing at other units. Oocyte survival after thawing was significantly higher at our center than following shipping to ancillary sites (78 vs. 63%, p = 0.047). Forty-nine women completed their treatment, either depleting their cryopreserved oocytes without conceiving (36) or attaining a live birth (13)—27% live birth rate per woman. Only one of eleven women who cryopreserved oocytes aged 40 and older had a live birth using thawed oocytes. Conclusion: Women should be advised to complete planned oocyte cryopreservation before age 40, given low success rates in women who underwent cryopreservation at advanced reproductive age. In this study, oocyte shipping was associated with lower survival rate. These findings may be relevant for women considering POC and utilization of cryopreserved oocytes.
KW - Advanced maternal age
KW - Age-related infertility
KW - Elective oocyte cryopreservation
KW - Oocyte shipping
KW - Oocyte thawing
KW - Oocyte transportation
KW - Planned oocyte cryopreservation
KW - Social egg freezing
UR - http://www.scopus.com/inward/record.url?scp=85140235464&partnerID=8YFLogxK
U2 - 10.1007/s10815-022-02633-7
DO - 10.1007/s10815-022-02633-7
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C2 - 36264444
AN - SCOPUS:85140235464
SN - 1058-0468
VL - 39
SP - 2625
EP - 2633
JO - Journal of Assisted Reproduction and Genetics
JF - Journal of Assisted Reproduction and Genetics
IS - 11
ER -