TY - JOUR
T1 - Clinical, psychological and thallium stress studies in patients with chest pain and normal coronary arteries
AU - Flugelman, Moshe Y.
AU - Weisstub, Eli
AU - Galun, Eithan
AU - Weiss, A. Teddy
AU - Fischer, Daniel
AU - De-Nour, Atara Kaplan
AU - Gotsman, Mervyn S.
AU - Eliakim, Marcel
PY - 1991/12
Y1 - 1991/12
N2 - The clinical and psychological profiles of 36 consecutive patients with chest pain and normal coronary arteries (study group) were compared to those of 34 patients with chest pain and significant coronary arterial disease (control group). All 70 patients were hospitalized for chest pain at least once prior to coronary angiography. The features of a typical episode of chest pain were similar in the normal coronary arteries and coronary arterial disease groups, but the female patients with normal coronary arteries had a shorter duration of a typical episode of chest pain, and the male patients with normal coronary arteries had a lower frequency of positive effort tests. Psychological testing showed the women with normal coronary arteries to have a tendency to increased somatization, anxiety, and a lower ability to identify origin of difficulties. The patients in the normal coronary and coronary arterial disease groups had psychological profiles typical of patients with chronic somatic disease. A psychiatric interview demonstrated an increased frequency of depressive trait (score 0-2) in the normal women (0.6 ± 0.8 vs 0, P < 0.05), and a tendency to increased somatization, anxiety, and sleeping disorders. Increased somatization was found in the normal coronary men (1.1 ± 0.7 vs 0.5 ± 0.7, P < 0.05). Twenty-five patients of the normal coronary group underwent quantitative thallium stress studies, and 13 patients (52%) had evidence of stress-induced myocardial perfusion defect. There were no differences in the clinical and psychological profiles of the patients with normal and those with pathological thallium stress tests. From our small group of patients we conclude that patients with chest pain and normal coronary arteries shared many clinical and psychological features with the patients who have coronary arterial disease. These similarities may be due to the fact that half of the patients with normal coronary arteries had an objective evidence of effort induced myocardial hypoperfusion.
AB - The clinical and psychological profiles of 36 consecutive patients with chest pain and normal coronary arteries (study group) were compared to those of 34 patients with chest pain and significant coronary arterial disease (control group). All 70 patients were hospitalized for chest pain at least once prior to coronary angiography. The features of a typical episode of chest pain were similar in the normal coronary arteries and coronary arterial disease groups, but the female patients with normal coronary arteries had a shorter duration of a typical episode of chest pain, and the male patients with normal coronary arteries had a lower frequency of positive effort tests. Psychological testing showed the women with normal coronary arteries to have a tendency to increased somatization, anxiety, and a lower ability to identify origin of difficulties. The patients in the normal coronary and coronary arterial disease groups had psychological profiles typical of patients with chronic somatic disease. A psychiatric interview demonstrated an increased frequency of depressive trait (score 0-2) in the normal women (0.6 ± 0.8 vs 0, P < 0.05), and a tendency to increased somatization, anxiety, and sleeping disorders. Increased somatization was found in the normal coronary men (1.1 ± 0.7 vs 0.5 ± 0.7, P < 0.05). Twenty-five patients of the normal coronary group underwent quantitative thallium stress studies, and 13 patients (52%) had evidence of stress-induced myocardial perfusion defect. There were no differences in the clinical and psychological profiles of the patients with normal and those with pathological thallium stress tests. From our small group of patients we conclude that patients with chest pain and normal coronary arteries shared many clinical and psychological features with the patients who have coronary arterial disease. These similarities may be due to the fact that half of the patients with normal coronary arteries had an objective evidence of effort induced myocardial hypoperfusion.
KW - Chest pain
KW - Clinical study
KW - Normal coronary artery
KW - Psychological study
KW - Thallium stress study
UR - http://www.scopus.com/inward/record.url?scp=0026055410&partnerID=8YFLogxK
U2 - 10.1016/0167-5273(91)90069-2
DO - 10.1016/0167-5273(91)90069-2
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C2 - 1761334
AN - SCOPUS:0026055410
SN - 0167-5273
VL - 33
SP - 401
EP - 408
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 3
ER -