Abstract
Chromosomal region Ilq23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and others. These translocations are associated with acute lymphocytic leukemia and acute myelomonocytic, monocytic, and myelogenous leukemia. From a yeast artificial chromosome containing human DNA derived from Hq23 we cloned a DNA fragment which can be used as a probe to detect rearrangements in leukemic cells from the majority of patients with the t(4;l 1), t(9;l 1), and t(l 1;19) translocations. The breakpoints cluster in a small DNA region of <5.8 kilobases.
Original language | English |
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Pages (from-to) | 6712-6714 |
Number of pages | 3 |
Journal | Cancer Research |
Volume | 51 |
Issue number | 24 |
State | Published - Dec 1991 |
Externally published | Yes |