Cloning ofALL-1, the Locus Involved in Leukemias with the t(4;ll)(q21;q23), t(9;ll)(p22;q23), and t(ll;19)(q23;pl3) Chromosome Translocations

G. Cimino; D. T. Moir; O. Canaani; K. Williams; W. M. Crist; S. Katzav; L. Cannizzaro; B. Lange; P. C. Nowell; C. M. Croce; E. Canaani

Cloning ofALL-1, the Locus Involved in Leukemias with the t(4;ll)(q21;q23), t(9;ll)(p22;q23), and t(ll;19)(q23;pl3) Chromosome Translocations

G. Cimino
, D. T. Moir
, O. Canaani
, K. Williams
, W. M. Crist
, S. Katzav
, L. Cannizzaro
, B. Lange
, P. C. Nowell
, C. M. Croce
, E. Canaani

Research output: Contribution to journal › Article › peer-review

219 Scopus citations

Abstract

Chromosomal region Ilq23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and others. These translocations are associated with acute lymphocytic leukemia and acute myelomonocytic, monocytic, and myelogenous leukemia. From a yeast artificial chromosome containing human DNA derived from Hq23 we cloned a DNA fragment which can be used as a probe to detect rearrangements in leukemic cells from the majority of patients with the t(4;l 1), t(9;l 1), and t(l 1;19) translocations. The breakpoints cluster in a small DNA region of <5.8 kilobases.

Original language	English
Pages (from-to)	6712-6714
Number of pages	3
Journal	Cancer Research
Volume	51
Issue number	24
State	Published - Dec 1991
Externally published	Yes

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Cite this

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title = "Cloning ofALL-1, the Locus Involved in Leukemias with the t(4;ll)(q21;q23), t(9;ll)(p22;q23), and t(ll;19)(q23;pl3) Chromosome Translocations",

abstract = "Chromosomal region Ilq23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and others. These translocations are associated with acute lymphocytic leukemia and acute myelomonocytic, monocytic, and myelogenous leukemia. From a yeast artificial chromosome containing human DNA derived from Hq23 we cloned a DNA fragment which can be used as a probe to detect rearrangements in leukemic cells from the majority of patients with the t(4;l 1), t(9;l 1), and t(l 1;19) translocations. The breakpoints cluster in a small DNA region of <5.8 kilobases.",

author = "G. Cimino and Moir, \{D. T.\} and O. Canaani and K. Williams and Crist, \{W. M.\} and S. Katzav and L. Cannizzaro and B. Lange and Nowell, \{P. C.\} and Croce, \{C. M.\} and E. Canaani",

year = "1991",

month = dec,

language = "אנגלית",

volume = "51",

pages = "6712--6714",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

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TY - JOUR

T1 - Cloning ofALL-1, the Locus Involved in Leukemias with the t(4;ll)(q21;q23), t(9;ll)(p22;q23), and t(ll;19)(q23;pl3) Chromosome Translocations

AU - Cimino, G.

AU - Moir, D. T.

AU - Canaani, O.

AU - Williams, K.

AU - Crist, W. M.

AU - Katzav, S.

AU - Cannizzaro, L.

AU - Lange, B.

AU - Nowell, P. C.

AU - Croce, C. M.

AU - Canaani, E.

PY - 1991/12

Y1 - 1991/12

N2 - Chromosomal region Ilq23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and others. These translocations are associated with acute lymphocytic leukemia and acute myelomonocytic, monocytic, and myelogenous leukemia. From a yeast artificial chromosome containing human DNA derived from Hq23 we cloned a DNA fragment which can be used as a probe to detect rearrangements in leukemic cells from the majority of patients with the t(4;l 1), t(9;l 1), and t(l 1;19) translocations. The breakpoints cluster in a small DNA region of <5.8 kilobases.

AB - Chromosomal region Ilq23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and others. These translocations are associated with acute lymphocytic leukemia and acute myelomonocytic, monocytic, and myelogenous leukemia. From a yeast artificial chromosome containing human DNA derived from Hq23 we cloned a DNA fragment which can be used as a probe to detect rearrangements in leukemic cells from the majority of patients with the t(4;l 1), t(9;l 1), and t(l 1;19) translocations. The breakpoints cluster in a small DNA region of <5.8 kilobases.

UR - https://www.scopus.com/pages/publications/0026335115

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 1835902

AN - SCOPUS:0026335115

SN - 0008-5472

VL - 51

SP - 6712

EP - 6714

JO - Cancer Research

JF - Cancer Research

IS - 24

ER -

Cloning ofALL-1, the Locus Involved in Leukemias with the t(4;ll)(q21;q23), t(9;ll)(p22;q23), and t(ll;19)(q23;pl3) Chromosome Translocations

Abstract

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