Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes

Ayelet Avraham, Steffen Jung, Yardena Samuels, Rony Seger, Yinon Ben-Neriah*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Previously we implicated c-Jun N-terminal kinase (JNK) as an element that is involved in signal integration during co-stimulation of T lymphocytes. This pathway has now been traced to an upper level, comprising MAPKK SEK1/MKK4/JNKK1 which, similarly to JNK, must receive input both from the TCR and CD28. A large portion of this input is probably integrated at the level of the Rho-family protein CDC42 which, here, activates SEK1 and JNK to the level reached by TCR and CD28 stimulation. We have identified another putative SEK/JNK pathway regulator, PKCθ, which in contrast to CDC42, activates SEK and JNK maximally only in conjunction with a calcium signal delivered through calcineurin. Signals originating at the TCR and CD28 may travel down the JNK pathway via PKCθ, calcineurin, CDC42, MEKK1 and SEK1.

Original languageAmerican English
Pages (from-to)2320-2330
Number of pages11
JournalEuropean Journal of Immunology
Volume28
Issue number8
DOIs
StatePublished - Aug 1998

Keywords

  • CD28
  • JNK-kinase activation
  • PKCθ
  • T cell co-stimulation
  • c-Jun N-terminal kinase

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