Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections

Yonatan M. Kupchik*, Robyn M. Brown, Jasper A. Heinsbroek, Mary Kay Lobo, Danielle J. Schwartz, Peter W. Kalivas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

312 Scopus citations


It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.

Original languageAmerican English
Pages (from-to)1230-1232
Number of pages3
JournalNature Neuroscience
Issue number9
StatePublished - 26 Aug 2015

Bibliographical note

Funding Information:
We thank T.C. Jhou and R.J. Smith for their assistance with the histology experiments. We thank E.J. Nestler (Mount Sinai School of Medicine) for providing D1-Cre and D2-Cre breeding pairs, and R. Gregory and J. Hyang for genotyping the mice. This work was supported by US Public Health Service grants DA03906, DA12513 and DA015369, and a fellowship from the Neuroscience Institute, Medical University of South Carolina.


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