Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections

Yonatan M. Kupchik; Robyn M. Brown; Jasper A. Heinsbroek; Mary Kay Lobo; Danielle J. Schwartz; Peter W. Kalivas

doi:10.1038/nn.4068

Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections

Yonatan M. Kupchik^*, Robyn M. Brown, Jasper A. Heinsbroek, Mary Kay Lobo, Danielle J. Schwartz, Peter W. Kalivas

^*Corresponding author for this work

Department of Medical Neurobiology

Research output: Contribution to journal › Article › peer-review

319 Scopus citations

Abstract

It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.

Original language	English
Pages (from-to)	1230-1232
Number of pages	3
Journal	Nature Neuroscience
Volume	18
Issue number	9
DOIs	https://doi.org/10.1038/nn.4068
State	Published - 26 Aug 2015

Bibliographical note

Funding Information:
We thank T.C. Jhou and R.J. Smith for their assistance with the histology experiments. We thank E.J. Nestler (Mount Sinai School of Medicine) for providing D1-Cre and D2-Cre breeding pairs, and R. Gregory and J. Hyang for genotyping the mice. This work was supported by US Public Health Service grants DA03906, DA12513 and DA015369, and a fellowship from the Neuroscience Institute, Medical University of South Carolina.

Access to Document

10.1038/nn.4068

Cite this

@article{0980a82f638748ac8bcdf565646911a3,

title = "Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections",

abstract = "It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.",

author = "Kupchik, {Yonatan M.} and Brown, {Robyn M.} and Heinsbroek, {Jasper A.} and Lobo, {Mary Kay} and Schwartz, {Danielle J.} and Kalivas, {Peter W.}",

note = "Funding Information: We thank T.C. Jhou and R.J. Smith for their assistance with the histology experiments. We thank E.J. Nestler (Mount Sinai School of Medicine) for providing D1-Cre and D2-Cre breeding pairs, and R. Gregory and J. Hyang for genotyping the mice. This work was supported by US Public Health Service grants DA03906, DA12513 and DA015369, and a fellowship from the Neuroscience Institute, Medical University of South Carolina.",

year = "2015",

month = aug,

day = "26",

doi = "10.1038/nn.4068",

language = "אנגלית",

volume = "18",

pages = "1230--1232",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Publishing Group",

number = "9",

}

TY - JOUR

T1 - Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections

AU - Kupchik, Yonatan M.

AU - Brown, Robyn M.

AU - Heinsbroek, Jasper A.

AU - Lobo, Mary Kay

AU - Schwartz, Danielle J.

AU - Kalivas, Peter W.

N1 - Funding Information: We thank T.C. Jhou and R.J. Smith for their assistance with the histology experiments. We thank E.J. Nestler (Mount Sinai School of Medicine) for providing D1-Cre and D2-Cre breeding pairs, and R. Gregory and J. Hyang for genotyping the mice. This work was supported by US Public Health Service grants DA03906, DA12513 and DA015369, and a fellowship from the Neuroscience Institute, Medical University of South Carolina.

PY - 2015/8/26

Y1 - 2015/8/26

N2 - It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.

AB - It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.

UR - http://www.scopus.com/inward/record.url?scp=84940460509&partnerID=8YFLogxK

U2 - 10.1038/nn.4068

DO - 10.1038/nn.4068

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 26214370

AN - SCOPUS:84940460509

SN - 1097-6256

VL - 18

SP - 1230

EP - 1232

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 9

ER -

Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this