Cognitive-performance recovery of Alzheimer's disease model mice by modulation of early soluble amyloidal assemblies

Anat Frydman-Marom*, Meirav Rechter, Irit Shefler, Yaron Bram, Deborah E. Shalev, Ehud Gazit

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

127 Scopus citations

Abstract

(Figure Presented) A rationally designed oligomerization inhibitor interacts with early intermediate assemblies of amyloid-β polypeptide (Aβ) through the aromatic elements and inhibits their assembly into the toxic oligomers that cause Alzheimer's disease by a unique Cα- methylation β-breakage strategy. The electrostatic potential of the low-energy conformation of the dipeptide inhibitor bound to Aβ is shown.

Original languageAmerican English
Pages (from-to)1981-1986
Number of pages6
JournalAngewandte Chemie - International Edition
Volume48
Issue number11
DOIs
StatePublished - 2 Mar 2009

Keywords

  • Amyloid assemblies
  • Inhibitors
  • Oligomers
  • Peptides
  • Self-assembly

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