Cognitive-performance recovery of Alzheimer's disease model mice by modulation of early soluble amyloidal assemblies

Anat Frydman-Marom; Meirav Rechter; Irit Shefler; Yaron Bram; Deborah E. Shalev; Ehud Gazit

doi:10.1002/anie.200802123

Cognitive-performance recovery of Alzheimer's disease model mice by modulation of early soluble amyloidal assemblies

Anat Frydman-Marom^*
, Meirav Rechter
, Irit Shefler
, Yaron Bram
, Deborah E. Shalev
, Ehud Gazit

^*Corresponding author for this work

Department of Biological Chemistry

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

(Figure Presented) A rationally designed oligomerization inhibitor interacts with early intermediate assemblies of amyloid-β polypeptide (Aβ) through the aromatic elements and inhibits their assembly into the toxic oligomers that cause Alzheimer's disease by a unique C^α- methylation β-breakage strategy. The electrostatic potential of the low-energy conformation of the dipeptide inhibitor bound to Aβ is shown.

Original language	English
Pages (from-to)	1981-1986
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	11
DOIs	https://doi.org/10.1002/anie.200802123
State	Published - 2 Mar 2009

Keywords

Amyloid assemblies
Inhibitors
Oligomers
Peptides
Self-assembly

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10.1002/anie.200802123

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abstract = "(Figure Presented) A rationally designed oligomerization inhibitor interacts with early intermediate assemblies of amyloid-β polypeptide (Aβ) through the aromatic elements and inhibits their assembly into the toxic oligomers that cause Alzheimer's disease by a unique Cα- methylation β-breakage strategy. The electrostatic potential of the low-energy conformation of the dipeptide inhibitor bound to Aβ is shown.",

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AU - Bram, Yaron

AU - Shalev, Deborah E.

AU - Gazit, Ehud

PY - 2009/3/2

Y1 - 2009/3/2

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AB - (Figure Presented) A rationally designed oligomerization inhibitor interacts with early intermediate assemblies of amyloid-β polypeptide (Aβ) through the aromatic elements and inhibits their assembly into the toxic oligomers that cause Alzheimer's disease by a unique Cα- methylation β-breakage strategy. The electrostatic potential of the low-energy conformation of the dipeptide inhibitor bound to Aβ is shown.

KW - Amyloid assemblies

KW - Inhibitors

KW - Oligomers

KW - Peptides

KW - Self-assembly

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Cognitive-performance recovery of Alzheimer's disease model mice by modulation of early soluble amyloidal assemblies

Abstract

Keywords

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