Cohen diabetic rat

Sarah Weksler-Zangen, Esther Orlanski, David H. Zangen

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

The Cohen diabetic (CD) rat is an experimental model of type 2 diabetes (T2D) originally developed by A. M. Cohen (1990) at the Hadassah University Hospital in Jerusalem, Israel. Two contrasting strains were derived by selective inbreeding: a sensitive (CDs) rat, which develops T2D only when fed a diabetogenic high-sucrose, copper-poor diet (HSD), and a resistant (CDr) rat that does not develop overt diabetes irrespective of diet. In the CDs rat, the development of T2D is directly attributed to beta-cell dysfunction and reduced insulin secretion (Weksler-Zangen et al. 2001, 2003a). Similarly to humans, in this rat model hyperglycemia is inducible and reversible by diet adjustment in the early stages of the disease (Cohen 1986). It also expresses many diabetes-related end-organ complications observed in humans, such as nephropathy and retinopathy. As in humans, the diabetic retinopathy and nephropathy in the Cohen rats exhibit pathological lesions in the early and end stages that closely resemble the development of these complications in humans (Cohen 1990; Cohen et al. 1993; Yagil et al. 2005).

Original languageAmerican English
Title of host publicationAnimal Models of Diabetes, Second Edition
Subtitle of host publicationFrontiers in Research
PublisherCRC Press
Pages323-334
Number of pages12
ISBN (Electronic)9781420009453
ISBN (Print)0849395348, 9780849395345
StatePublished - 1 Jan 2007
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2007 by Taylor & Francis Group, LLC.

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