Abstract
The Cohen diabetic (CD) rat is an experimental model of type 2 diabetes (T2D) originally developed by A. M. Cohen (1990) at the Hadassah University Hospital in Jerusalem, Israel. Two contrasting strains were derived by selective inbreeding: a sensitive (CDs) rat, which develops T2D only when fed a diabetogenic high-sucrose, copper-poor diet (HSD), and a resistant (CDr) rat that does not develop overt diabetes irrespective of diet. In the CDs rat, the development of T2D is directly attributed to beta-cell dysfunction and reduced insulin secretion (Weksler-Zangen et al. 2001, 2003a). Similarly to humans, in this rat model hyperglycemia is inducible and reversible by diet adjustment in the early stages of the disease (Cohen 1986). It also expresses many diabetes-related end-organ complications observed in humans, such as nephropathy and retinopathy. As in humans, the diabetic retinopathy and nephropathy in the Cohen rats exhibit pathological lesions in the early and end stages that closely resemble the development of these complications in humans (Cohen 1990; Cohen et al. 1993; Yagil et al. 2005).
| Original language | English |
|---|---|
| Title of host publication | Animal Models of Diabetes, Second Edition |
| Subtitle of host publication | Frontiers in Research |
| Publisher | CRC Press |
| Pages | 323-334 |
| Number of pages | 12 |
| ISBN (Electronic) | 9781420009453 |
| ISBN (Print) | 0849395348, 9780849395345 |
| State | Published - 1 Jan 2007 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2007 by Taylor & Francis Group, LLC.
