Coherent activation of DNA tweezers: A "SET-RESET" logic system

Johann Elbaz; Michal Moshe; Itamar Willner

doi:10.1002/anie.200805819

Coherent activation of DNA tweezers: A "SET-RESET" logic system

Johann Elbaz^*, Michal Moshe, Itamar Willner

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

150 Scopus citations

Abstract

Open sesame: Aptamer-substrate complexes activate the coherent operation of two tweezers that act as a "SET-RESET" logic system. Each tweezer cycles between a fluorescent open state and a closed quenched state (Q=quencher, F=fluorophore) when triggered by adenosine monophosphate (AMP) and adenosine deaminase (AD).

Original language	English
Pages (from-to)	3834-3837
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	21
DOIs	https://doi.org/10.1002/anie.200805819
State	Published - 11 May 2009

Keywords

Aptamers
DNA machinesl logic gates
Molecular devices
Tweezers

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10.1002/anie.200805819

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abstract = "Open sesame: Aptamer-substrate complexes activate the coherent operation of two tweezers that act as a {"}SET-RESET{"} logic system. Each tweezer cycles between a fluorescent open state and a closed quenched state (Q=quencher, F=fluorophore) when triggered by adenosine monophosphate (AMP) and adenosine deaminase (AD).",

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KW - DNA machinesl logic gates

KW - Molecular devices

KW - Tweezers

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Coherent activation of DNA tweezers: A "SET-RESET" logic system

Abstract

Keywords

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