Abstract
Binding kinetics of receptor arrays can differ dramatically from that of the isolated receptor. We simulate synaptic transmission using a microscopically accurate Brownian dynamics routine. We study the factors governing the rise and decay of the activation probability as a function of the number of transmitter molecules released. Using a realistic receptor array geometry, the simulation reproduces the time course of α-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated excitatory postsynaptic currents. A consistent interpretation of experimentally observed synaptic currents in terms of rebinding and spatial correlations is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 1582-1594 |
| Number of pages | 13 |
| Journal | Biophysical Journal |
| Volume | 72 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1997 |