TY - JOUR
T1 - Colorectal Cancer at the Crossroads
T2 - The Good, the Bad, and the Future of Platinum-Based Drugs
AU - Kee, Jia Xuan
AU - Yau, Jia Ning Nicolette
AU - Kumar Muthuramalingam, Ram Pravin
AU - Wang, Xinyi
AU - Chng, Wei Heng
AU - Lopez-Sanchez, Alvaro
AU - Tay, Kevin Kuang Wei
AU - Deng, Lih Wen
AU - Gibson, Dan
AU - Bertrand, Helene C.
AU - Adriani, Giulia
AU - Ang, Wee Han
AU - Pastorin, Giorgia
N1 - Publisher Copyright:
© 2025 The Authors. Published by American Chemical Society
PY - 2025/11/12
Y1 - 2025/11/12
N2 - Colorectal cancer (CRC) remains a significant global health challenge, ranking third in incidence and second in mortality among cancers worldwide. This review addresses the complex landscape of CRC, focusing on incidence, mortality trends, preventive strategies, and the evolving therapeutic approaches, particularly highlighting the role of platinum-based drugs like oxaliplatin (OXP). It also underscores the increasing burden of CRC, with factors such as westernized diets, aging populations, and genetic predispositions contributing to its prevalence. Therapeutically, early detection greatly enhances survival rates, emphasizing the importance of regular colonoscopies and stool tests. For advanced CRC, chemotherapy remains pivotal, with OXP as a cornerstone treatment despite its associated chemotherapy-induced peripheral neurotoxicity (CIPN). The review explores innovative strategies to overcome challenges related to chemotherapy, such as drug resistance and side effects, highlighting recent developments in the field, such as Pt(IV) prodrugs and immunotherapeutic approaches to enhance efficacy while minimizing toxicity. Additionally, this manuscript examines experimental models for drug screening, emphasizing the role of murine models and advanced 3D in vitro systems in CRC research. Overall, the review advocates for a comprehensive approach, integrating prevention, early detection, and personalized treatments to alleviate the global burden of CRC.
AB - Colorectal cancer (CRC) remains a significant global health challenge, ranking third in incidence and second in mortality among cancers worldwide. This review addresses the complex landscape of CRC, focusing on incidence, mortality trends, preventive strategies, and the evolving therapeutic approaches, particularly highlighting the role of platinum-based drugs like oxaliplatin (OXP). It also underscores the increasing burden of CRC, with factors such as westernized diets, aging populations, and genetic predispositions contributing to its prevalence. Therapeutically, early detection greatly enhances survival rates, emphasizing the importance of regular colonoscopies and stool tests. For advanced CRC, chemotherapy remains pivotal, with OXP as a cornerstone treatment despite its associated chemotherapy-induced peripheral neurotoxicity (CIPN). The review explores innovative strategies to overcome challenges related to chemotherapy, such as drug resistance and side effects, highlighting recent developments in the field, such as Pt(IV) prodrugs and immunotherapeutic approaches to enhance efficacy while minimizing toxicity. Additionally, this manuscript examines experimental models for drug screening, emphasizing the role of murine models and advanced 3D in vitro systems in CRC research. Overall, the review advocates for a comprehensive approach, integrating prevention, early detection, and personalized treatments to alleviate the global burden of CRC.
UR - https://www.scopus.com/pages/publications/105021378019
U2 - 10.1021/acs.chemrev.5c00041
DO - 10.1021/acs.chemrev.5c00041
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C2 - 40985211
AN - SCOPUS:105021378019
SN - 0009-2665
VL - 125
SP - 10248
EP - 10341
JO - Chemical Reviews
JF - Chemical Reviews
IS - 21
ER -