TY - JOUR
T1 - Commitment to meiosis
T2 - What determines the mode of division in budding yeast?
AU - Simchen, Giora
PY - 2009
Y1 - 2009
N2 - In budding yeast, commitment to meiosis is attained when meiotic cells cannot return to the mitotic cell cycle even if the triggering cue (nutrients deprivation) is withdrawn. Commitment is arrived at gradually, and different aspects of meiosis may be committed at different times. Cells become fully committed to meiosis at the end of Prophase I, long after DNA replication and just before the first meiotic division (MI). Whole-genome gene expression analysis has shown that committed cells have a distinct and rapid response to nutrients, and are not simply insulated from environmental signals. Thus becoming committed to meiosis is an active process. The cellular event most likely to be associated with commitment to meiosis is the separation of the duplicated spindle-pole bodies (SPBs) and the formation of the spindle. Commitment to the mitotic cell cycle is also associated with the separation of SPBs, although it occurs in G1, before DNA replication.
AB - In budding yeast, commitment to meiosis is attained when meiotic cells cannot return to the mitotic cell cycle even if the triggering cue (nutrients deprivation) is withdrawn. Commitment is arrived at gradually, and different aspects of meiosis may be committed at different times. Cells become fully committed to meiosis at the end of Prophase I, long after DNA replication and just before the first meiotic division (MI). Whole-genome gene expression analysis has shown that committed cells have a distinct and rapid response to nutrients, and are not simply insulated from environmental signals. Thus becoming committed to meiosis is an active process. The cellular event most likely to be associated with commitment to meiosis is the separation of the duplicated spindle-pole bodies (SPBs) and the formation of the spindle. Commitment to the mitotic cell cycle is also associated with the separation of SPBs, although it occurs in G1, before DNA replication.
KW - Cell cycle
KW - Cellular differentiation
KW - Commitment
KW - Meiosis
UR - http://www.scopus.com/inward/record.url?scp=62849090790&partnerID=8YFLogxK
U2 - 10.1002/bies.200800124
DO - 10.1002/bies.200800124
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C2 - 19204989
AN - SCOPUS:62849090790
SN - 0265-9247
VL - 31
SP - 169
EP - 177
JO - BioEssays
JF - BioEssays
IS - 2
ER -