TY - JOUR
T1 - Commitment to the mitotic cell cycle in yeast in relation to meiosis
AU - Hirschberg, J.
AU - Simchen, G.
PY - 1977/3/15
Y1 - 1977/3/15
N2 - Under restrictive vegetative conditions, cells of cell-division cycle (cdc) temperature-sensitive mutants arrest at specific points in the cycle. Meiotic and mitotic behaviour of such arrested cells was examined under permissive sporulation conditions. Those mutants which were committed to mitosis at their specific point of arrest finished the cell cycle and could only then go into meiosis. It was found that commitment to mitosis occurred early in the cell cycle, prior to DNA replication, and that this commitment was dependent upon the gene function of cdc4.
AB - Under restrictive vegetative conditions, cells of cell-division cycle (cdc) temperature-sensitive mutants arrest at specific points in the cycle. Meiotic and mitotic behaviour of such arrested cells was examined under permissive sporulation conditions. Those mutants which were committed to mitosis at their specific point of arrest finished the cell cycle and could only then go into meiosis. It was found that commitment to mitosis occurred early in the cell cycle, prior to DNA replication, and that this commitment was dependent upon the gene function of cdc4.
UR - http://www.scopus.com/inward/record.url?scp=0017576358&partnerID=8YFLogxK
U2 - 10.1016/0014-4827(77)90122-7
DO - 10.1016/0014-4827(77)90122-7
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C2 - 321229
AN - SCOPUS:0017576358
SN - 0014-4827
VL - 105
SP - 245
EP - 252
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 2
ER -