TY - JOUR
T1 - Comparative pharmacokinetic analysis of a novel sustained release dosage form of valproic acid in dogs
AU - Bialer, Meir
AU - Friedman, Michael
AU - Dubrovsky, Joseph
PY - 1984
Y1 - 1984
N2 - A new sustained release dosage form of valproic acid (VPA) was developed. The new sustained release dosage form was administered (twice, with and without food) to five dogs in comparison to a standard tablet (Depakine, Labaz) and an i.v. preparation of the drug. Drug level monitoring in the plasma was performed by a GLC assay. Results indicate that the sustained release formulation exhibited a more prolonged and uniform absorption rate, yielded more sustained plasma levels after ingestion, and showed an overall bioavailability of 0·84 (95 per cent C.I. = 0·72, 0·96) relative to an equivalent dose of a conventional tablet.
AB - A new sustained release dosage form of valproic acid (VPA) was developed. The new sustained release dosage form was administered (twice, with and without food) to five dogs in comparison to a standard tablet (Depakine, Labaz) and an i.v. preparation of the drug. Drug level monitoring in the plasma was performed by a GLC assay. Results indicate that the sustained release formulation exhibited a more prolonged and uniform absorption rate, yielded more sustained plasma levels after ingestion, and showed an overall bioavailability of 0·84 (95 per cent C.I. = 0·72, 0·96) relative to an equivalent dose of a conventional tablet.
KW - Antiepileptic
KW - Pharmacokinetics
KW - Sustained release dosage form
KW - Valproic acid
UR - http://www.scopus.com/inward/record.url?scp=0021333759&partnerID=8YFLogxK
U2 - 10.1002/bdd.2510050102
DO - 10.1002/bdd.2510050102
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C2 - 6423010
AN - SCOPUS:0021333759
SN - 0142-2782
VL - 5
SP - 1
EP - 10
JO - Biopharmaceutics and Drug Disposition
JF - Biopharmaceutics and Drug Disposition
IS - 1
ER -