TY - JOUR
T1 - Comparative Study of Predominant Phytochemical Compounds and Proapoptotic Potential of Broccoli Sprouts and Florets
AU - Paśko, Paweł
AU - Tyszka-Czochara, Małgorzata
AU - Galanty, Agnieszka
AU - Gdula-Argasińska, Joanna
AU - Żmudzki, Paweł
AU - Bartoń, Henryk
AU - Zagrodzki, Paweł
AU - Gorinstein, Shela
N1 - Publisher Copyright:
© 2018, The Author(s).
PY - 2018/6/1
Y1 - 2018/6/1
N2 - The study compares lyophilized broccoli sprouts and florets in terms of their chemical composition, cytotoxic and proapoptotic potential against hepatocellular carcinoma HepG2, colorectal cancer SW480, and skin fibroblast BJ cells. Sinapic and isochlorogenic acids were predominant phenolics in the sprouts and florets, respectively. The amount of sulforaphane in the sprouts was significantly higher vs. florets. Oleic and linoleic acids dominated in the sprouts, while caproic, stearic and oleic acids in the florets. Broccoli sprouts were selectively cytotoxic on HepG2 and SW480 cells, with proapoptotic effect for the latter, while the florets were less selective, but more active, with profound proapoptotic effect for HepG2 cells (77.4%). Thus, lyophilized broccoli sprouts may be effectively used in dietary chemoprevention.
AB - The study compares lyophilized broccoli sprouts and florets in terms of their chemical composition, cytotoxic and proapoptotic potential against hepatocellular carcinoma HepG2, colorectal cancer SW480, and skin fibroblast BJ cells. Sinapic and isochlorogenic acids were predominant phenolics in the sprouts and florets, respectively. The amount of sulforaphane in the sprouts was significantly higher vs. florets. Oleic and linoleic acids dominated in the sprouts, while caproic, stearic and oleic acids in the florets. Broccoli sprouts were selectively cytotoxic on HepG2 and SW480 cells, with proapoptotic effect for the latter, while the florets were less selective, but more active, with profound proapoptotic effect for HepG2 cells (77.4%). Thus, lyophilized broccoli sprouts may be effectively used in dietary chemoprevention.
KW - Apoptosis
KW - Broccoli sprouts and florets
KW - Fatty acids
KW - Freeze-dried products
KW - Sulforaphane
UR - http://www.scopus.com/inward/record.url?scp=85045742038&partnerID=8YFLogxK
U2 - 10.1007/s11130-018-0665-2
DO - 10.1007/s11130-018-0665-2
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C2 - 29675806
AN - SCOPUS:85045742038
SN - 0921-9668
VL - 73
SP - 95
EP - 100
JO - Plant Foods for Human Nutrition
JF - Plant Foods for Human Nutrition
IS - 2
ER -
