TY - JOUR
T1 - Comparing two measures of creatinine clearance
T2 - An application of errors-in-variables and bootstrap techniques
AU - Oman, Samuel D.
AU - Meir, Natalia
AU - Haim, Nissim
PY - 1999
Y1 - 1999
N2 - Two indices of creatinine clearance (an index of kidney function) are compared on a group of cancer patients who underwent chemotherapy with a potentially nephrotoxic drug. The standard index, measured creatinine clearance MCC, is cumbersome to use, whereas the more convenient alternative, estimated creatinine clearance ECC, has not yet been conclusively evaluated on cancer patients. We conclude that under certain clinical conditions ECC and MCC are identically calibrated for males, but not for females, and we obtain estimated true and false positive rates for assessing the use of ECC instead of MCC as a diagnostic tool. We use a model that is formally equivalent to an errors-in-variables model with (unbalanced) repeated observations and correlated measurement errors. The bootstrap is used to obtain standard errors and confidence limits.
AB - Two indices of creatinine clearance (an index of kidney function) are compared on a group of cancer patients who underwent chemotherapy with a potentially nephrotoxic drug. The standard index, measured creatinine clearance MCC, is cumbersome to use, whereas the more convenient alternative, estimated creatinine clearance ECC, has not yet been conclusively evaluated on cancer patients. We conclude that under certain clinical conditions ECC and MCC are identically calibrated for males, but not for females, and we obtain estimated true and false positive rates for assessing the use of ECC instead of MCC as a diagnostic tool. We use a model that is formally equivalent to an errors-in-variables model with (unbalanced) repeated observations and correlated measurement errors. The bootstrap is used to obtain standard errors and confidence limits.
KW - Calibration
KW - Repeated measures
KW - Structural model
KW - True and false positive rates
UR - http://www.scopus.com/inward/record.url?scp=0033478921&partnerID=8YFLogxK
U2 - 10.1111/1467-9876.00138
DO - 10.1111/1467-9876.00138
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AN - SCOPUS:0033478921
SN - 0035-9254
VL - 48
SP - 39
EP - 52
JO - Journal of the Royal Statistical Society. Series C: Applied Statistics
JF - Journal of the Royal Statistical Society. Series C: Applied Statistics
IS - 1
ER -