Comparing two measures of creatinine clearance: An application of errors-in-variables and bootstrap techniques

Samuel D. Oman*, Natalia Meir, Nissim Haim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Two indices of creatinine clearance (an index of kidney function) are compared on a group of cancer patients who underwent chemotherapy with a potentially nephrotoxic drug. The standard index, measured creatinine clearance MCC, is cumbersome to use, whereas the more convenient alternative, estimated creatinine clearance ECC, has not yet been conclusively evaluated on cancer patients. We conclude that under certain clinical conditions ECC and MCC are identically calibrated for males, but not for females, and we obtain estimated true and false positive rates for assessing the use of ECC instead of MCC as a diagnostic tool. We use a model that is formally equivalent to an errors-in-variables model with (unbalanced) repeated observations and correlated measurement errors. The bootstrap is used to obtain standard errors and confidence limits.

Original languageEnglish
Pages (from-to)39-52
Number of pages14
JournalJournal of the Royal Statistical Society. Series C: Applied Statistics
Volume48
Issue number1
DOIs
StatePublished - 1999

Keywords

  • Calibration
  • Repeated measures
  • Structural model
  • True and false positive rates

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