Comparison of μ opioid receptors in brains of rats bred for high or low rate of self-stimulation

Ruth Gross-Isseroff; Edna Cohen; Yehuda Shavit

doi:10.1016/0031-9384(92)90099-N

Comparison of μ opioid receptors in brains of rats bred for high or low rate of self-stimulation

Ruth Gross-Isseroff^*, Edna Cohen, Yehuda Shavit

^*Corresponding author for this work

Department of Psychology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Opiates and endogenous opioid peptides play an important role in reward-mediated behaviors, including self-stimulation. Two strains of rats, LC2-Hi and LC2-Lo, selectively bred for high vs. low rate of lateral hypothalamic self-stimulation, were employed in the present study. Quantitative autoradiography was performed on brains of adult male rats of each strain, using the μ opioid receptor agonist ³H-DAGO. Strain differences in receptor density were observed in the nucleus accumbens and in ventral areas of the hippocampus.

Original language	English
Pages (from-to)	1093-1096
Number of pages	4
Journal	Physiology and Behavior
Volume	51
Issue number	5
DOIs	https://doi.org/10.1016/0031-9384(92)90099-N
State	Published - May 1992

Keywords

H-DAGO
Autoradiography
Genetic strains
Nucleus accumbens
Reward
Self-stimulation
μ opioid receptors

Access to Document

10.1016/0031-9384(92)90099-N

Cite this

@article{aac9d32ecf404cfa94dd186fcdd7bf71,

title = "Comparison of μ opioid receptors in brains of rats bred for high or low rate of self-stimulation",

abstract = "Opiates and endogenous opioid peptides play an important role in reward-mediated behaviors, including self-stimulation. Two strains of rats, LC2-Hi and LC2-Lo, selectively bred for high vs. low rate of lateral hypothalamic self-stimulation, were employed in the present study. Quantitative autoradiography was performed on brains of adult male rats of each strain, using the μ opioid receptor agonist 3H-DAGO. Strain differences in receptor density were observed in the nucleus accumbens and in ventral areas of the hippocampus.",

keywords = "H-DAGO, Autoradiography, Genetic strains, Nucleus accumbens, Reward, Self-stimulation, μ opioid receptors",

author = "Ruth Gross-Isseroff and Edna Cohen and Yehuda Shavit",

year = "1992",

month = may,

doi = "10.1016/0031-9384(92)90099-N",

language = "אנגלית",

volume = "51",

pages = "1093--1096",

journal = "Physiology and Behavior",

issn = "0031-9384",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Comparison of μ opioid receptors in brains of rats bred for high or low rate of self-stimulation

AU - Gross-Isseroff, Ruth

AU - Cohen, Edna

AU - Shavit, Yehuda

PY - 1992/5

Y1 - 1992/5

N2 - Opiates and endogenous opioid peptides play an important role in reward-mediated behaviors, including self-stimulation. Two strains of rats, LC2-Hi and LC2-Lo, selectively bred for high vs. low rate of lateral hypothalamic self-stimulation, were employed in the present study. Quantitative autoradiography was performed on brains of adult male rats of each strain, using the μ opioid receptor agonist 3H-DAGO. Strain differences in receptor density were observed in the nucleus accumbens and in ventral areas of the hippocampus.

AB - Opiates and endogenous opioid peptides play an important role in reward-mediated behaviors, including self-stimulation. Two strains of rats, LC2-Hi and LC2-Lo, selectively bred for high vs. low rate of lateral hypothalamic self-stimulation, were employed in the present study. Quantitative autoradiography was performed on brains of adult male rats of each strain, using the μ opioid receptor agonist 3H-DAGO. Strain differences in receptor density were observed in the nucleus accumbens and in ventral areas of the hippocampus.

KW - H-DAGO

KW - Autoradiography

KW - Genetic strains

KW - Nucleus accumbens

KW - Reward

KW - Self-stimulation

KW - μ opioid receptors

UR - http://www.scopus.com/inward/record.url?scp=0026777193&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(92)90099-N

DO - 10.1016/0031-9384(92)90099-N

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 1319588

AN - SCOPUS:0026777193

SN - 0031-9384

VL - 51

SP - 1093

EP - 1096

JO - Physiology and Behavior

JF - Physiology and Behavior

IS - 5

ER -

Comparison of μ opioid receptors in brains of rats bred for high or low rate of self-stimulation

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this