Comparison of μ opioid receptors in brains of rats bred for high or low rate of self-stimulation

Ruth Gross-Isseroff; Edna Cohen; Yehuda Shavit

doi:10.1016/0031-9384(92)90099-N

Comparison of μ opioid receptors in brains of rats bred for high or low rate of self-stimulation

Ruth Gross-Isseroff^*
, Edna Cohen
, Yehuda Shavit

^*Corresponding author for this work

Department of Psychology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Opiates and endogenous opioid peptides play an important role in reward-mediated behaviors, including self-stimulation. Two strains of rats, LC2-Hi and LC2-Lo, selectively bred for high vs. low rate of lateral hypothalamic self-stimulation, were employed in the present study. Quantitative autoradiography was performed on brains of adult male rats of each strain, using the μ opioid receptor agonist ³H-DAGO. Strain differences in receptor density were observed in the nucleus accumbens and in ventral areas of the hippocampus.

Original language	English
Pages (from-to)	1093-1096
Number of pages	4
Journal	Physiology and Behavior
Volume	51
Issue number	5
DOIs	https://doi.org/10.1016/0031-9384(92)90099-N
State	Published - May 1992

Keywords

Autoradiography
Genetic strains
H-DAGO
Nucleus accumbens
Reward
Self-stimulation
μ opioid receptors

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10.1016/0031-9384(92)90099-N

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title = "Comparison of μ opioid receptors in brains of rats bred for high or low rate of self-stimulation",

abstract = "Opiates and endogenous opioid peptides play an important role in reward-mediated behaviors, including self-stimulation. Two strains of rats, LC2-Hi and LC2-Lo, selectively bred for high vs. low rate of lateral hypothalamic self-stimulation, were employed in the present study. Quantitative autoradiography was performed on brains of adult male rats of each strain, using the μ opioid receptor agonist 3H-DAGO. Strain differences in receptor density were observed in the nucleus accumbens and in ventral areas of the hippocampus.",

keywords = "Autoradiography, Genetic strains, H-DAGO, Nucleus accumbens, Reward, Self-stimulation, μ opioid receptors",

author = "Ruth Gross-Isseroff and Edna Cohen and Yehuda Shavit",

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doi = "10.1016/0031-9384(92)90099-N",

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AU - Gross-Isseroff, Ruth

AU - Cohen, Edna

AU - Shavit, Yehuda

PY - 1992/5

Y1 - 1992/5

N2 - Opiates and endogenous opioid peptides play an important role in reward-mediated behaviors, including self-stimulation. Two strains of rats, LC2-Hi and LC2-Lo, selectively bred for high vs. low rate of lateral hypothalamic self-stimulation, were employed in the present study. Quantitative autoradiography was performed on brains of adult male rats of each strain, using the μ opioid receptor agonist 3H-DAGO. Strain differences in receptor density were observed in the nucleus accumbens and in ventral areas of the hippocampus.

AB - Opiates and endogenous opioid peptides play an important role in reward-mediated behaviors, including self-stimulation. Two strains of rats, LC2-Hi and LC2-Lo, selectively bred for high vs. low rate of lateral hypothalamic self-stimulation, were employed in the present study. Quantitative autoradiography was performed on brains of adult male rats of each strain, using the μ opioid receptor agonist 3H-DAGO. Strain differences in receptor density were observed in the nucleus accumbens and in ventral areas of the hippocampus.

KW - Autoradiography

KW - Genetic strains

KW - H-DAGO

KW - Nucleus accumbens

KW - Reward

KW - Self-stimulation

KW - μ opioid receptors

UR - https://www.scopus.com/pages/publications/0026777193

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AN - SCOPUS:0026777193

SN - 0031-9384

VL - 51

SP - 1093

EP - 1096

JO - Physiology and Behavior

JF - Physiology and Behavior

IS - 5

ER -

Comparison of μ opioid receptors in brains of rats bred for high or low rate of self-stimulation

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Keywords

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