Abstract
Objectives: Candida albicans is a common fungal infection and is commensal in 40–65 % of healthy adults. The development and pharmacokinetics of a novel sustained release clotrimazole varnish (Clot-SRV) for topical oral use have been reported. The aim of this study was to compare the efficacy of this varnish with clotrimazole troche treatment of oral candidiasis. Materials and methods: Of the 12 patients with denture stomatitis treated for 14 days, six used Clot-SRV (study group) and six clotrimazole troches (control). The patients were instructed to use Clot-SRV (50 mg of clotrimazole) once a day, and the control group was instructed to use five troches of 10 mg clotrimazole/day. Microbiological samples were obtained from saliva, buccal mucosa, palate, and denture. The degree of erythema was recorded at three time points, and subjective opinions noted using a questionnaire. Results: At the end of the study, the control group had relatively more cases of erythema on all examined surfaces; patients who applied the Clot-SRV had significantly lower levels of candida on the denture surfaces and in saliva, and had better compliance to the medication. Conclusions: The novel clotrimazole sustained release varnish may be an important part of a new protocol for oral candidiasis, with improved clinical outcomes.
Original language | English |
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Pages (from-to) | 467-473 |
Number of pages | 7 |
Journal | Clinical Oral Investigations |
Volume | 19 |
Issue number | 2 |
DOIs | |
State | Published - Mar 2015 |
Bibliographical note
Funding Information:This study was partially supported by the P&G Innovation Award.
Publisher Copyright:
© 2014, Springer-Verlag Berlin Heidelberg.
Keywords
- Candidiasis
- Clotrimazole
- Oral
- Sustained release
- Varnish