Comparison of the toxicity of two trichothecenes applied topically to brain and liver of rats

Felix Bergmann; Rinah Yarom; Boris Yagen

doi:10.1016/0378-4274(89)90185-9

Comparison of the toxicity of two trichothecenes applied topically to brain and liver of rats

Felix Bergmann^*, Rinah Yarom, Boris Yagen

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

T-2 toxin has been found previously to be markedly more toxic upon intracerebral than upon systemic administration. In order to study the generality of this difference, we have applied to brain and liver of albino rats two different types of trichothecenes: T-2 toxin as a representative of 'simple' and myrotoxin B as a representative of 'macrocyclic' members of this series. Myrotoxin B, when applied intracerebrally, was about 100 times more poisonous than T-2 toxin. In contrast, upon intrahepatic injection both compounds exhibited similar degrees of toxicity. The different behavior of the two trichothecenes in the organs tested may be due to local metabolic factors.

Original language	English
Pages (from-to)	49-56
Number of pages	8
Journal	Toxicology Letters
Volume	48
Issue number	1
DOIs	https://doi.org/10.1016/0378-4274(89)90185-9
State	Published - Jul 1989

Keywords

Brainstem and liver
Myrotoxin B
T-2 Toxin
Topical administration
Toxicity

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10.1016/0378-4274(89)90185-9

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title = "Comparison of the toxicity of two trichothecenes applied topically to brain and liver of rats",

abstract = "T-2 toxin has been found previously to be markedly more toxic upon intracerebral than upon systemic administration. In order to study the generality of this difference, we have applied to brain and liver of albino rats two different types of trichothecenes: T-2 toxin as a representative of 'simple' and myrotoxin B as a representative of 'macrocyclic' members of this series. Myrotoxin B, when applied intracerebrally, was about 100 times more poisonous than T-2 toxin. In contrast, upon intrahepatic injection both compounds exhibited similar degrees of toxicity. The different behavior of the two trichothecenes in the organs tested may be due to local metabolic factors.",

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author = "Felix Bergmann and Rinah Yarom and Boris Yagen",

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T1 - Comparison of the toxicity of two trichothecenes applied topically to brain and liver of rats

AU - Bergmann, Felix

AU - Yarom, Rinah

AU - Yagen, Boris

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N2 - T-2 toxin has been found previously to be markedly more toxic upon intracerebral than upon systemic administration. In order to study the generality of this difference, we have applied to brain and liver of albino rats two different types of trichothecenes: T-2 toxin as a representative of 'simple' and myrotoxin B as a representative of 'macrocyclic' members of this series. Myrotoxin B, when applied intracerebrally, was about 100 times more poisonous than T-2 toxin. In contrast, upon intrahepatic injection both compounds exhibited similar degrees of toxicity. The different behavior of the two trichothecenes in the organs tested may be due to local metabolic factors.

AB - T-2 toxin has been found previously to be markedly more toxic upon intracerebral than upon systemic administration. In order to study the generality of this difference, we have applied to brain and liver of albino rats two different types of trichothecenes: T-2 toxin as a representative of 'simple' and myrotoxin B as a representative of 'macrocyclic' members of this series. Myrotoxin B, when applied intracerebrally, was about 100 times more poisonous than T-2 toxin. In contrast, upon intrahepatic injection both compounds exhibited similar degrees of toxicity. The different behavior of the two trichothecenes in the organs tested may be due to local metabolic factors.

KW - Brainstem and liver

KW - Myrotoxin B

KW - T-2 Toxin

KW - Topical administration

KW - Toxicity

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JO - Toxicology Letters

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Comparison of the toxicity of two trichothecenes applied topically to brain and liver of rats

Abstract

Keywords

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