Competitive fungal commensalism mitigates candidiasis pathology

Jarmila Sekeresova Kralova; Catalina Donic; Bareket Dassa; Ilana Livyatan; Paul Mathias Jansen; Shifra Ben-Dor; Lena Fidel; Sébastien Trzebanski; Lian Narunsky-Haziza; Omer Asraf; Ori Brenner; Hagit Dafni; Ghil Jona; Sigalit Boura-Halfon; Noa Stettner; Eran Segal; Sascha Brunke; Yitzhak Pilpel; Ravid Straussman; David Zeevi; Petra Bacher; Bernhard Hube; Neta Shlezinger; Steffen Jung

doi:10.1084/jem.20231686

Competitive fungal commensalism mitigates candidiasis pathology

Jarmila Sekeresova Kralova, Catalina Donic, Bareket Dassa, Ilana Livyatan, Paul Mathias Jansen, Shifra Ben-Dor, Lena Fidel, Sébastien Trzebanski, Lian Narunsky-Haziza, Omer Asraf, Ori Brenner, Hagit Dafni, Ghil Jona, Sigalit Boura-Halfon, Noa Stettner, Eran Segal, Sascha Brunke, Yitzhak Pilpel, Ravid Straussman, David ZeeviPetra Bacher, Bernhard Hube, Neta Shlezinger, Steffen Jung

The Koret School of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The mycobiota are a critical part of the gut microbiome, but host-fungal interactions and specific functional contributions of commensal fungi to host fitness remain incompletely understood. Here, we report the identification of a new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization and significantly reduced the commensal C. albicans burden in colonized animals. Following immunosuppression of C. albicans colonized mice, competitive fungal commensalism thereby mitigated fatal candidiasis. Metagenome analysis revealed K. heterogenica or K. weizmannii presence among human commensals. Our results reveal competitive fungal commensalism within the intestinal microbiota, independent of bacteria and immune responses, that could bear potential therapeutic value for the management of C. albicans-mediated diseases.

Original language	English
Journal	Journal of Experimental Medicine
Volume	221
Issue number	5
DOIs	https://doi.org/10.1084/jem.20231686
State	Published - 6 May 2024

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© 2024 Sekeresova Kralova et al.

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Sekeresova Kralova, J., Donic, C., Dassa, B., Livyatan, I., Jansen, P. M., Ben-Dor, S., Fidel, L., Trzebanski, S., Narunsky-Haziza, L., Asraf, O., Brenner, O., Dafni, H., Jona, G., Boura-Halfon, S., Stettner, N., Segal, E., Brunke, S., Pilpel, Y., Straussman, R., ... Jung, S. (2024). Competitive fungal commensalism mitigates candidiasis pathology. Journal of Experimental Medicine, 221(5). https://doi.org/10.1084/jem.20231686

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title = "Competitive fungal commensalism mitigates candidiasis pathology",

abstract = "The mycobiota are a critical part of the gut microbiome, but host-fungal interactions and specific functional contributions of commensal fungi to host fitness remain incompletely understood. Here, we report the identification of a new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization and significantly reduced the commensal C. albicans burden in colonized animals. Following immunosuppression of C. albicans colonized mice, competitive fungal commensalism thereby mitigated fatal candidiasis. Metagenome analysis revealed K. heterogenica or K. weizmannii presence among human commensals. Our results reveal competitive fungal commensalism within the intestinal microbiota, independent of bacteria and immune responses, that could bear potential therapeutic value for the management of C. albicans-mediated diseases.",

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Sekeresova Kralova, J, Donic, C, Dassa, B, Livyatan, I, Jansen, PM, Ben-Dor, S, Fidel, L, Trzebanski, S, Narunsky-Haziza, L, Asraf, O, Brenner, O, Dafni, H, Jona, G, Boura-Halfon, S, Stettner, N, Segal, E, Brunke, S, Pilpel, Y, Straussman, R, Zeevi, D, Bacher, P, Hube, B, Shlezinger, N & Jung, S 2024, 'Competitive fungal commensalism mitigates candidiasis pathology', Journal of Experimental Medicine, vol. 221, no. 5. https://doi.org/10.1084/jem.20231686

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AU - Sekeresova Kralova, Jarmila

AU - Donic, Catalina

AU - Dassa, Bareket

AU - Livyatan, Ilana

AU - Jansen, Paul Mathias

AU - Ben-Dor, Shifra

AU - Fidel, Lena

AU - Trzebanski, Sébastien

AU - Narunsky-Haziza, Lian

AU - Asraf, Omer

AU - Brenner, Ori

AU - Dafni, Hagit

AU - Jona, Ghil

AU - Boura-Halfon, Sigalit

AU - Stettner, Noa

AU - Segal, Eran

AU - Brunke, Sascha

AU - Pilpel, Yitzhak

AU - Straussman, Ravid

AU - Zeevi, David

AU - Bacher, Petra

AU - Hube, Bernhard

AU - Shlezinger, Neta

AU - Jung, Steffen

PY - 2024/5/6

Y1 - 2024/5/6

N2 - The mycobiota are a critical part of the gut microbiome, but host-fungal interactions and specific functional contributions of commensal fungi to host fitness remain incompletely understood. Here, we report the identification of a new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization and significantly reduced the commensal C. albicans burden in colonized animals. Following immunosuppression of C. albicans colonized mice, competitive fungal commensalism thereby mitigated fatal candidiasis. Metagenome analysis revealed K. heterogenica or K. weizmannii presence among human commensals. Our results reveal competitive fungal commensalism within the intestinal microbiota, independent of bacteria and immune responses, that could bear potential therapeutic value for the management of C. albicans-mediated diseases.

AB - The mycobiota are a critical part of the gut microbiome, but host-fungal interactions and specific functional contributions of commensal fungi to host fitness remain incompletely understood. Here, we report the identification of a new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization and significantly reduced the commensal C. albicans burden in colonized animals. Following immunosuppression of C. albicans colonized mice, competitive fungal commensalism thereby mitigated fatal candidiasis. Metagenome analysis revealed K. heterogenica or K. weizmannii presence among human commensals. Our results reveal competitive fungal commensalism within the intestinal microbiota, independent of bacteria and immune responses, that could bear potential therapeutic value for the management of C. albicans-mediated diseases.

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Competitive fungal commensalism mitigates candidiasis pathology

Abstract

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