Composition-Tailoring of ZnO-Hydroxyapatite Nanocomposite as Bioactive and Antibacterial Coating

Ori Geuli, Israel Lewinstein, Daniel Mandler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Overcoming postimplantation infections is considered as a major challenge in medicine, where continuous efforts have been invested in developing bactericidal functional coatings. The synergic combination of hydroxyapatite (HAp) and ZnO holds beneficial properties, such as excellent bioactivity that is reinforced with its antibacterial nature. Here, highly phase tunable pure ZnO-HAp nanocomposite coatings were fabricated via electrophoretic deposition. HAp and ZnO nanoparticles were synthesized separately, dispersed simultaneously, and coelectrophoretically deposited onto a titanium substrate. By manipulating the deposition potentials, a single-stage graded-coating of ZnO-HAp was successfully obtained. In addition, by controlling the composition of the nanomaterials in the dispersions, we managed to precisely tailor composite coatings with a dictated phase ratio between ZnO and HAp. In vitro studies, bioactivity, cytotoxicity, and antibacterial tests, showed excellent performance by enhancing the mineralization of the coating and improving cells proliferation while successfully eradicating E. coli bacteria.

Original languageAmerican English
Pages (from-to)2946-2957
Number of pages12
JournalACS Applied Nano Materials
Issue number5
StatePublished - 24 May 2019

Bibliographical note

Publisher Copyright:
© 2019 American Chemical Society.


  • ZnO
  • antibacterial
  • electrophoretic deposition
  • hydroxyapatite
  • nanoparticles


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