Computational and experimental analysis of the transmembrane domain 4/5 dimerization interface of the serotonin 5-HT_1A receptor

Keyphrases

• Transmembrane Domain 100%
• Dimer Interface 100%
• Resonance Energy Transfer 100%
• Serotonin 5-HT1A Receptor 100%
• Dimerization 66%
• G Protein-coupled Receptor 66%
• 5-HT1A Receptor 66%
• Homomer 66%
• Oligomerization 33%
• Computational Modeling 33%
• Physiological Role 33%
• Protein-protein Docking 33%
• Model Dynamics 33%
• Molecular Dynamics Simulation 33%
• Heteromer 33%
• Functional Studies 33%
• Site-directed mutagenesis 33%
• Rationally Designed 33%
• Serotonin 33%
• Receptor Dimerization 33%
• Refined Model 33%
• Transfer Approach 33%
• Amino Acid Interactions 33%
• Optimized Model 33%
• Acceptor Photobleaching 33%
• Dimer Model 33%
• Interaction Interface 33%
• Dimer Structure 33%
• Predicted Contacts 33%
• Serotonin (5-HT) Receptors 33%

Biochemistry, Genetics and Molecular Biology

• Transmembrane Domain 100%
• Dimerization 100%
• Energy Transfer 100%
• 5-HT1A Receptor 100%
• G Protein Coupled Receptor 66%
• Wild Type 66%
• Serotonin 66%
• Amino Acids 33%
• Dynamics 33%
• Oligomerization 33%
• Signal Recognition Particle Receptor 33%
• Site-Directed Mutagenesis 33%
• Photobleaching 33%
• Heteromer 33%
• 5-HT Receptor 33%