Computational design of an integrin I domain stabilized in the open high affinity conformation

Keyphrases

• High Affinity 100%
• Computational Design 100%
• Integrin 100%
• I-domain 100%
• Ligand Binding 33%
• Large Proteins 16%
• Receptor Binding 16%
• Conformational Change 16%
• Transmembrane Domain 16%
• Cell Surface 16%
• Protein Domain 16%
• Physiologically Relevant 16%
• Alternative Conformations 16%
• Computational Approach 16%
• Hydrophobic Core 16%
• IC3b 16%
• Human Expert 16%
• Conformation Change 16%
• Complement C3 16%

Biochemistry, Genetics and Molecular Biology

• Conformation 100%
• Integrin 100%
• Ligand Binding 66%
• Wild Type 66%
• Conformational Change 33%
• Receptor Binding 33%
• Transmembrane Domain 33%
• IC3b 33%
• Complement Component 3 33%
• Protein Tertiary Structure 33%