Computer analysis of the entire budding yeast genome for putative targets of the GCN4 transcription factor

Oren Schuldiner, Chen Yanover, Nissim Benvenisty*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The completion of the yeast genome project enables an analysis of various phenomena for a whole eukaryotic genome. We aimed at characterizing a full spectrum of target genes for a transcription activator, and specifically characterized putative targets for GCN4 in the budding yeast. The results suggest that about 1% of the genes are regulated by GCN4 and that these genes code for proteins involved in amino-acid and nucleotide metabolism. Our analysis proposes that, when enough data about the binding nature of a transcription factor exists, it is possible to identify its putative targets and also to try and assign a physiological role for this transcription factor.

Original languageAmerican English
Pages (from-to)16-20
Number of pages5
JournalCurrent Genetics
Volume33
Issue number1
DOIs
StatePublished - Jan 1998

Bibliographical note

Funding Information:
Acknowledgements We thank Dr. Bat-Sheva Kerem, Dr. Shosha-na Klein and Dr. David Engelberg for critical reviewing the manuscript. This research was supported by grant #3811 a from The Council for Tobacco Research and by grant #93-00017 from the United-States–Israel Binational Science Foundation (BSF), Jerusalem, Israel.

Keywords

  • GCN4
  • Genome
  • S. cerevisiae
  • Transcription factor

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