Computer analysis of the entire budding yeast genome for putative targets of the GCN4 transcription factor

Oren Schuldiner; Chen Yanover; Nissim Benvenisty

doi:10.1007/s002940050303

Computer analysis of the entire budding yeast genome for putative targets of the GCN4 transcription factor

Oren Schuldiner, Chen Yanover, Nissim Benvenisty^*

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The completion of the yeast genome project enables an analysis of various phenomena for a whole eukaryotic genome. We aimed at characterizing a full spectrum of target genes for a transcription activator, and specifically characterized putative targets for GCN4 in the budding yeast. The results suggest that about 1% of the genes are regulated by GCN4 and that these genes code for proteins involved in amino-acid and nucleotide metabolism. Our analysis proposes that, when enough data about the binding nature of a transcription factor exists, it is possible to identify its putative targets and also to try and assign a physiological role for this transcription factor.

Original language	English
Pages (from-to)	16-20
Number of pages	5
Journal	Current Genetics
Volume	33
Issue number	1
DOIs	https://doi.org/10.1007/s002940050303
State	Published - Jan 1998

Bibliographical note

Funding Information:
Acknowledgements We thank Dr. Bat-Sheva Kerem, Dr. Shosha-na Klein and Dr. David Engelberg for critical reviewing the manuscript. This research was supported by grant #3811 a from The Council for Tobacco Research and by grant #93-00017 from the United-States–Israel Binational Science Foundation (BSF), Jerusalem, Israel.

Keywords

GCN4
Genome
S. cerevisiae
Transcription factor

Access to Document

10.1007/s002940050303

Cite this

@article{a3e7bb9f0e054d1e95fd2618aeb61122,

title = "Computer analysis of the entire budding yeast genome for putative targets of the GCN4 transcription factor",

abstract = "The completion of the yeast genome project enables an analysis of various phenomena for a whole eukaryotic genome. We aimed at characterizing a full spectrum of target genes for a transcription activator, and specifically characterized putative targets for GCN4 in the budding yeast. The results suggest that about 1% of the genes are regulated by GCN4 and that these genes code for proteins involved in amino-acid and nucleotide metabolism. Our analysis proposes that, when enough data about the binding nature of a transcription factor exists, it is possible to identify its putative targets and also to try and assign a physiological role for this transcription factor.",

keywords = "GCN4, Genome, S. cerevisiae, Transcription factor",

author = "Oren Schuldiner and Chen Yanover and Nissim Benvenisty",

note = "Funding Information: Acknowledgements We thank Dr. Bat-Sheva Kerem, Dr. Shosha-na Klein and Dr. David Engelberg for critical reviewing the manuscript. This research was supported by grant #3811 a from The Council for Tobacco Research and by grant #93-00017 from the United-States–Israel Binational Science Foundation (BSF), Jerusalem, Israel.",

year = "1998",

month = jan,

doi = "10.1007/s002940050303",

language = "אנגלית",

volume = "33",

pages = "16--20",

journal = "Current Genetics",

issn = "0172-8083",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - Computer analysis of the entire budding yeast genome for putative targets of the GCN4 transcription factor

AU - Schuldiner, Oren

AU - Yanover, Chen

AU - Benvenisty, Nissim

N1 - Funding Information: Acknowledgements We thank Dr. Bat-Sheva Kerem, Dr. Shosha-na Klein and Dr. David Engelberg for critical reviewing the manuscript. This research was supported by grant #3811 a from The Council for Tobacco Research and by grant #93-00017 from the United-States–Israel Binational Science Foundation (BSF), Jerusalem, Israel.

PY - 1998/1

Y1 - 1998/1

N2 - The completion of the yeast genome project enables an analysis of various phenomena for a whole eukaryotic genome. We aimed at characterizing a full spectrum of target genes for a transcription activator, and specifically characterized putative targets for GCN4 in the budding yeast. The results suggest that about 1% of the genes are regulated by GCN4 and that these genes code for proteins involved in amino-acid and nucleotide metabolism. Our analysis proposes that, when enough data about the binding nature of a transcription factor exists, it is possible to identify its putative targets and also to try and assign a physiological role for this transcription factor.

AB - The completion of the yeast genome project enables an analysis of various phenomena for a whole eukaryotic genome. We aimed at characterizing a full spectrum of target genes for a transcription activator, and specifically characterized putative targets for GCN4 in the budding yeast. The results suggest that about 1% of the genes are regulated by GCN4 and that these genes code for proteins involved in amino-acid and nucleotide metabolism. Our analysis proposes that, when enough data about the binding nature of a transcription factor exists, it is possible to identify its putative targets and also to try and assign a physiological role for this transcription factor.

KW - GCN4

KW - Genome

KW - S. cerevisiae

KW - Transcription factor

UR - http://www.scopus.com/inward/record.url?scp=0031931222&partnerID=8YFLogxK

U2 - 10.1007/s002940050303

DO - 10.1007/s002940050303

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 9472075

AN - SCOPUS:0031931222

SN - 0172-8083

VL - 33

SP - 16

EP - 20

JO - Current Genetics

JF - Current Genetics

IS - 1

ER -

Computer analysis of the entire budding yeast genome for putative targets of the GCN4 transcription factor

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this