TY - JOUR
T1 - Computerized cognitive testing battery identifies mild cognitive impairment and mild dementia even in the presence of depressive symptoms
AU - Doniger, Glen M.
AU - Dwolatzky, Tzvi
AU - Zucker, David M.
AU - Chertkow, Howard
AU - Crystal, Howard
AU - Schweiger, Avraham
AU - Simon, Ely S.
PY - 2006
Y1 - 2006
N2 - Cognitive and depressive symptoms co-occur, complicating detection of mild cognitive impairment (MCI) and early dementia. In this study, discriminant validity of a novel computerized cognitive battery for MCI detection was evaluated after covariation for depressive symptom severity. In addition to the computerized battery, participants at two sites received the 30-item self-administered Geriatric Depression Scale (GDS; n = 72); those at two other centers received the observer-administered Cornell Scale for Depression in Dementia (CSDD; n = 88). In both cohorts, a Global Cognitive Score and memory, executive function, visual spatial, and verbal index scores discriminated among cognitively healthy, MCI, and mild dementia groups after covariation for GDS or CSDD, respectively (p < 0.05). Thus, the computerized battery for detection of mild impairment is robust to comorbid depressive symptoms, supporting its clinical utility in identifying neurodegenerative disease even in elderly with depression.
AB - Cognitive and depressive symptoms co-occur, complicating detection of mild cognitive impairment (MCI) and early dementia. In this study, discriminant validity of a novel computerized cognitive battery for MCI detection was evaluated after covariation for depressive symptom severity. In addition to the computerized battery, participants at two sites received the 30-item self-administered Geriatric Depression Scale (GDS; n = 72); those at two other centers received the observer-administered Cornell Scale for Depression in Dementia (CSDD; n = 88). In both cohorts, a Global Cognitive Score and memory, executive function, visual spatial, and verbal index scores discriminated among cognitively healthy, MCI, and mild dementia groups after covariation for GDS or CSDD, respectively (p < 0.05). Thus, the computerized battery for detection of mild impairment is robust to comorbid depressive symptoms, supporting its clinical utility in identifying neurodegenerative disease even in elderly with depression.
KW - Cognitive assessment
KW - Computerized battery
KW - Dementia
KW - Depression
KW - Mild cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=33644551859&partnerID=8YFLogxK
U2 - 10.1177/153331750602100105
DO - 10.1177/153331750602100105
M3 - Article
C2 - 16526587
AN - SCOPUS:33644551859
SN - 1533-3175
VL - 21
SP - 28
EP - 36
JO - American Journal of Alzheimer's Disease and other Dementias
JF - American Journal of Alzheimer's Disease and other Dementias
IS - 1
ER -