Computerized model for evaluating the kinetics of in vitro release of valpromide from controlled‐release tablets under nonsink conditions

A general mathematical model was developed to describe a dissolution system for tablets that have undergone attrition and maintained their geometric shape as concentration changed, i.e., starting with sink and ending with nonsink conditions. A computer program, designed for the microcomputer, was used to test the goodness of fit of the experimental data to the theoretical data by the χ² test. This program is more significant than a previous published program that relates to the more specific kinetic analysis of multidispersed powders undergoing dissolution under sink conditions. Concentration data obtained after dissolution tests of valpromide (2‐propylvaleramide) controlled‐release tablets performed under changing concentration conditions were checked in the two computerized models, which showed a better fit to the general model.