TY - JOUR
T1 - COMT
T2 - A common susceptibility gene in bipolar disorder and schizophrenia
AU - Shifman, Sagiv
AU - Bronstein, Michal
AU - Sternfeld, Meira
AU - Pisanté, Anne
AU - Weizman, Avraham
AU - Reznik, Ilya
AU - Spivak, Baruch
AU - Grisaru, Nimrod
AU - Karp, Leon
AU - Schiffer, Richard
AU - Kotler, Moshe
AU - Strous, Rael D.
AU - Swartz-Vanetik, Marnina
AU - Knobler, Haim Y.
AU - Shinar, Eilat
AU - Yakir, Benjamin
AU - Zak, Naomi B.
AU - Darvasi, Ariel
PY - 2004/7/1
Y1 - 2004/7/1
N2 - A variety of psychiatric illnesses, including schizophrenia and bipolar disorder, have been reported in patients with microdeletion on chromosome 22q11-a region which includes the catechol-O-methyltransferase (COMT) gene. The variety of psychiatric manifestations in patients with the 22q11 microdeletion and the role of COMT in the degradation of catecholamine neurotransmitters may thus suggest a general involvement of the COMT gene in psychiatric diseases. We have previously reported on a significant association between a COMT haplotype and schizophrenia. In this study, we attempt to test for association between bipolar disorder and the polymorphisms implicated in schizophrenia. The association between COMT and bipolar disorder was tested by examining the allele and haplotype found to be associated with schizophrenia. A significant association between bipolar disorder and COMT polymorphisms was found. The estimated relative risk is greater in women, a result consistent with our previous findings in schizophrenia. We suggest that polymorphisms in the COMT gene may influence susceptibility to both diseases-and probably also a wider range of behavioral traits.
AB - A variety of psychiatric illnesses, including schizophrenia and bipolar disorder, have been reported in patients with microdeletion on chromosome 22q11-a region which includes the catechol-O-methyltransferase (COMT) gene. The variety of psychiatric manifestations in patients with the 22q11 microdeletion and the role of COMT in the degradation of catecholamine neurotransmitters may thus suggest a general involvement of the COMT gene in psychiatric diseases. We have previously reported on a significant association between a COMT haplotype and schizophrenia. In this study, we attempt to test for association between bipolar disorder and the polymorphisms implicated in schizophrenia. The association between COMT and bipolar disorder was tested by examining the allele and haplotype found to be associated with schizophrenia. A significant association between bipolar disorder and COMT polymorphisms was found. The estimated relative risk is greater in women, a result consistent with our previous findings in schizophrenia. We suggest that polymorphisms in the COMT gene may influence susceptibility to both diseases-and probably also a wider range of behavioral traits.
KW - Ashkenazi Jews
KW - Association
KW - Bipolar affective disorder
KW - Catechol-O-methyltransferase
KW - Linkage disequilibrium
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=3042806953&partnerID=8YFLogxK
U2 - 10.1002/ajmg.b.30032
DO - 10.1002/ajmg.b.30032
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AN - SCOPUS:3042806953
SN - 1552-4841
VL - 128 B
SP - 61
EP - 64
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
IS - 1
ER -