COMT: A common susceptibility gene in bipolar disorder and schizophrenia

Sagiv Shifman; Michal Bronstein; Meira Sternfeld; Anne Pisanté; Avraham Weizman; Ilya Reznik; Baruch Spivak; Nimrod Grisaru; Leon Karp; Richard Schiffer; Moshe Kotler; Rael D. Strous; Marnina Swartz-Vanetik; Haim Y. Knobler; Eilat Shinar; Benjamin Yakir; Naomi B. Zak; Ariel Darvasi

doi:10.1002/ajmg.b.30032

COMT: A common susceptibility gene in bipolar disorder and schizophrenia

Sagiv Shifman, Michal Bronstein, Meira Sternfeld, Anne Pisanté, Avraham Weizman, Ilya Reznik, Baruch Spivak, Nimrod Grisaru, Leon Karp, Richard Schiffer, Moshe Kotler, Rael D. Strous, Marnina Swartz-Vanetik, Haim Y. Knobler, Eilat Shinar, Benjamin Yakir, Naomi B. Zak, Ariel Darvasi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

A variety of psychiatric illnesses, including schizophrenia and bipolar disorder, have been reported in patients with microdeletion on chromosome 22q11-a region which includes the catechol-O-methyltransferase (COMT) gene. The variety of psychiatric manifestations in patients with the 22q11 microdeletion and the role of COMT in the degradation of catecholamine neurotransmitters may thus suggest a general involvement of the COMT gene in psychiatric diseases. We have previously reported on a significant association between a COMT haplotype and schizophrenia. In this study, we attempt to test for association between bipolar disorder and the polymorphisms implicated in schizophrenia. The association between COMT and bipolar disorder was tested by examining the allele and haplotype found to be associated with schizophrenia. A significant association between bipolar disorder and COMT polymorphisms was found. The estimated relative risk is greater in women, a result consistent with our previous findings in schizophrenia. We suggest that polymorphisms in the COMT gene may influence susceptibility to both diseases-and probably also a wider range of behavioral traits.

Original language	American English
Pages (from-to)	61-64
Number of pages	4
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	128 B
Issue number	1
DOIs	https://doi.org/10.1002/ajmg.b.30032
State	Published - 1 Jul 2004

Keywords

Ashkenazi Jews
Association
Bipolar affective disorder
Catechol-O-methyltransferase
Linkage disequilibrium
Schizophrenia

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10.1002/ajmg.b.30032

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Shifman, S., Bronstein, M., Sternfeld, M., Pisanté, A., Weizman, A., Reznik, I., Spivak, B., Grisaru, N., Karp, L., Schiffer, R., Kotler, M., Strous, R. D., Swartz-Vanetik, M., Knobler, H. Y., Shinar, E., Yakir, B., Zak, N. B., & Darvasi, A. (2004). COMT: A common susceptibility gene in bipolar disorder and schizophrenia. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 128 B(1), 61-64. https://doi.org/10.1002/ajmg.b.30032

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title = "COMT: A common susceptibility gene in bipolar disorder and schizophrenia",

abstract = "A variety of psychiatric illnesses, including schizophrenia and bipolar disorder, have been reported in patients with microdeletion on chromosome 22q11-a region which includes the catechol-O-methyltransferase (COMT) gene. The variety of psychiatric manifestations in patients with the 22q11 microdeletion and the role of COMT in the degradation of catecholamine neurotransmitters may thus suggest a general involvement of the COMT gene in psychiatric diseases. We have previously reported on a significant association between a COMT haplotype and schizophrenia. In this study, we attempt to test for association between bipolar disorder and the polymorphisms implicated in schizophrenia. The association between COMT and bipolar disorder was tested by examining the allele and haplotype found to be associated with schizophrenia. A significant association between bipolar disorder and COMT polymorphisms was found. The estimated relative risk is greater in women, a result consistent with our previous findings in schizophrenia. We suggest that polymorphisms in the COMT gene may influence susceptibility to both diseases-and probably also a wider range of behavioral traits.",

keywords = "Ashkenazi Jews, Association, Bipolar affective disorder, Catechol-O-methyltransferase, Linkage disequilibrium, Schizophrenia",

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Shifman, S, Bronstein, M, Sternfeld, M, Pisanté, A, Weizman, A, Reznik, I, Spivak, B, Grisaru, N, Karp, L, Schiffer, R, Kotler, M, Strous, RD, Swartz-Vanetik, M, Knobler, HY, Shinar, E, Yakir, B, Zak, NB & Darvasi, A 2004, 'COMT: A common susceptibility gene in bipolar disorder and schizophrenia', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 128 B, no. 1, pp. 61-64. https://doi.org/10.1002/ajmg.b.30032

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AU - Shifman, Sagiv

AU - Bronstein, Michal

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AU - Pisanté, Anne

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AU - Reznik, Ilya

AU - Spivak, Baruch

AU - Grisaru, Nimrod

AU - Karp, Leon

AU - Schiffer, Richard

AU - Kotler, Moshe

AU - Strous, Rael D.

AU - Swartz-Vanetik, Marnina

AU - Knobler, Haim Y.

AU - Shinar, Eilat

AU - Yakir, Benjamin

AU - Zak, Naomi B.

AU - Darvasi, Ariel

PY - 2004/7/1

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N2 - A variety of psychiatric illnesses, including schizophrenia and bipolar disorder, have been reported in patients with microdeletion on chromosome 22q11-a region which includes the catechol-O-methyltransferase (COMT) gene. The variety of psychiatric manifestations in patients with the 22q11 microdeletion and the role of COMT in the degradation of catecholamine neurotransmitters may thus suggest a general involvement of the COMT gene in psychiatric diseases. We have previously reported on a significant association between a COMT haplotype and schizophrenia. In this study, we attempt to test for association between bipolar disorder and the polymorphisms implicated in schizophrenia. The association between COMT and bipolar disorder was tested by examining the allele and haplotype found to be associated with schizophrenia. A significant association between bipolar disorder and COMT polymorphisms was found. The estimated relative risk is greater in women, a result consistent with our previous findings in schizophrenia. We suggest that polymorphisms in the COMT gene may influence susceptibility to both diseases-and probably also a wider range of behavioral traits.

AB - A variety of psychiatric illnesses, including schizophrenia and bipolar disorder, have been reported in patients with microdeletion on chromosome 22q11-a region which includes the catechol-O-methyltransferase (COMT) gene. The variety of psychiatric manifestations in patients with the 22q11 microdeletion and the role of COMT in the degradation of catecholamine neurotransmitters may thus suggest a general involvement of the COMT gene in psychiatric diseases. We have previously reported on a significant association between a COMT haplotype and schizophrenia. In this study, we attempt to test for association between bipolar disorder and the polymorphisms implicated in schizophrenia. The association between COMT and bipolar disorder was tested by examining the allele and haplotype found to be associated with schizophrenia. A significant association between bipolar disorder and COMT polymorphisms was found. The estimated relative risk is greater in women, a result consistent with our previous findings in schizophrenia. We suggest that polymorphisms in the COMT gene may influence susceptibility to both diseases-and probably also a wider range of behavioral traits.

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KW - Bipolar affective disorder

KW - Catechol-O-methyltransferase

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IS - 1

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COMT: A common susceptibility gene in bipolar disorder and schizophrenia

Abstract

Keywords

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