Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues

Dmitry Tsvelikhovsky, Stephen L. Buchwald*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

127 Scopus citations


A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.

Original languageAmerican English
Pages (from-to)14228-14231
Number of pages4
JournalJournal of the American Chemical Society
Issue number36
StatePublished - 14 Sep 2011
Externally publishedYes


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