TY - JOUR
T1 - Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues
AU - Tsvelikhovsky, Dmitry
AU - Buchwald, Stephen L.
PY - 2011/9/14
Y1 - 2011/9/14
N2 - A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.
AB - A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.
UR - http://www.scopus.com/inward/record.url?scp=80052559866&partnerID=8YFLogxK
U2 - 10.1021/ja206229y
DO - 10.1021/ja206229y
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 21838278
AN - SCOPUS:80052559866
SN - 0002-7863
VL - 133
SP - 14228
EP - 14231
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 36
ER -