Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues

Dmitry Tsvelikhovsky; Stephen L. Buchwald

doi:10.1021/ja206229y

Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues

Dmitry Tsvelikhovsky, Stephen L. Buchwald^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.

Original language	American English
Pages (from-to)	14228-14231
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	133
Issue number	36
DOIs	https://doi.org/10.1021/ja206229y
State	Published - 14 Sep 2011
Externally published	Yes

Access to Document

10.1021/ja206229y

Cite this

@article{8165d170ec554e8ba9cf49bf4e63fa27,

title = "Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues",

abstract = "A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.",

author = "Dmitry Tsvelikhovsky and Buchwald, {Stephen L.}",

year = "2011",

month = sep,

day = "14",

doi = "10.1021/ja206229y",

language = "American English",

volume = "133",

pages = "14228--14231",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "36",

}

TY - JOUR

T1 - Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues

AU - Tsvelikhovsky, Dmitry

AU - Buchwald, Stephen L.

PY - 2011/9/14

Y1 - 2011/9/14

N2 - A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.

AB - A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.

UR - http://www.scopus.com/inward/record.url?scp=80052559866&partnerID=8YFLogxK

U2 - 10.1021/ja206229y

DO - 10.1021/ja206229y

M3 - Article

C2 - 21838278

AN - SCOPUS:80052559866

SN - 0002-7863

VL - 133

SP - 14228

EP - 14231

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 36

ER -

Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues

Abstract

Access to Document

Other files and links

Fingerprint

Cite this