Conformational analysis of somatostatin and selected analogs in oriented polyoxyethylene by infrared dichroism

C. Gilon, D. Simmons, M. Goodman*, J. Rivier

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Infrared dichroic studies and deuterium exchange measurements of somatostatin and some of its analogs incorporated in uniaxially oriented polyoxyethylene are described. Band positions and dichroic ratios in the N‐H stretching and amide I and II regions are similar to those of flexible and nonordered peptides like valinomycin and poly[Glu(ONa)]. This information, together with fast deuterium exchange rates, suggests that somatostatin exists in a flexible nonordered conformation in polyoxyethylene. One analog, di‐S3,14‐acetamidomethyl dihydrosomatostatin, was found to exist in both nonordered and β‐like conformations.

Original languageEnglish
Pages (from-to)341-352
Number of pages12
JournalBiopolymers
Volume19
Issue number2
DOIs
StatePublished - Feb 1980

Fingerprint

Dive into the research topics of 'Conformational analysis of somatostatin and selected analogs in oriented polyoxyethylene by infrared dichroism'. Together they form a unique fingerprint.

Cite this