Congenital bilateral absence of vas deferens in the absence of cystic fibrosis

A. Augarten; Y. Yahav; J. Laufer; A. Szeinberg; J. Dor; S. Mashiach; I. Madgar; D. Halle; E. Gazit; B. S. Kerem

doi:10.1016/S0140-6736(94)90292-5

Congenital bilateral absence of vas deferens in the absence of cystic fibrosis

A. Augarten^*, Y. Yahav, J. Laufer, A. Szeinberg, J. Dor, S. Mashiach, I. Madgar, D. Halle, E. Gazit, B. S. Kerem

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

The high frequency of mutations in the cystic fibrosis gene in patients with congenital bilateral absence of vas deferens (CBAVD) has raised the question whether all of them have a genital form of cystic fibrosis. We investigated 47 CBAVD patients by ultrasonography, 10 (21%) had renal malformations and 37 (79%) did not. In the former group, no cystic fibrosis mutations were found and sweat chloride concentrations were normal. In the latter group, 18 patients (49%) carried at least one cystic fibrosis mutation and sweat chloride was high in 17 of 26 tested (65%). Our findings suggest that CBAVD patients with renal malformations do not necessarily have cystic fibrosis.

Original language	English
Pages (from-to)	1473-1474
Number of pages	2
Journal	The Lancet
Volume	344
Issue number	8935
DOIs	https://doi.org/10.1016/S0140-6736(94)90292-5
State	Published - 26 Nov 1994

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title = "Congenital bilateral absence of vas deferens in the absence of cystic fibrosis",

abstract = "The high frequency of mutations in the cystic fibrosis gene in patients with congenital bilateral absence of vas deferens (CBAVD) has raised the question whether all of them have a genital form of cystic fibrosis. We investigated 47 CBAVD patients by ultrasonography, 10 (21%) had renal malformations and 37 (79%) did not. In the former group, no cystic fibrosis mutations were found and sweat chloride concentrations were normal. In the latter group, 18 patients (49%) carried at least one cystic fibrosis mutation and sweat chloride was high in 17 of 26 tested (65%). Our findings suggest that CBAVD patients with renal malformations do not necessarily have cystic fibrosis.",

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T1 - Congenital bilateral absence of vas deferens in the absence of cystic fibrosis

AU - Augarten, A.

AU - Yahav, Y.

AU - Laufer, J.

AU - Szeinberg, A.

AU - Dor, J.

AU - Mashiach, S.

AU - Madgar, I.

AU - Halle, D.

AU - Gazit, E.

AU - Kerem, B. S.

PY - 1994/11/26

Y1 - 1994/11/26

N2 - The high frequency of mutations in the cystic fibrosis gene in patients with congenital bilateral absence of vas deferens (CBAVD) has raised the question whether all of them have a genital form of cystic fibrosis. We investigated 47 CBAVD patients by ultrasonography, 10 (21%) had renal malformations and 37 (79%) did not. In the former group, no cystic fibrosis mutations were found and sweat chloride concentrations were normal. In the latter group, 18 patients (49%) carried at least one cystic fibrosis mutation and sweat chloride was high in 17 of 26 tested (65%). Our findings suggest that CBAVD patients with renal malformations do not necessarily have cystic fibrosis.

AB - The high frequency of mutations in the cystic fibrosis gene in patients with congenital bilateral absence of vas deferens (CBAVD) has raised the question whether all of them have a genital form of cystic fibrosis. We investigated 47 CBAVD patients by ultrasonography, 10 (21%) had renal malformations and 37 (79%) did not. In the former group, no cystic fibrosis mutations were found and sweat chloride concentrations were normal. In the latter group, 18 patients (49%) carried at least one cystic fibrosis mutation and sweat chloride was high in 17 of 26 tested (65%). Our findings suggest that CBAVD patients with renal malformations do not necessarily have cystic fibrosis.

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Congenital bilateral absence of vas deferens in the absence of cystic fibrosis

Abstract

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