TY - JOUR
T1 - Conservation and divergence in the transcriptional programs of the human and mouse immune systems
AU - ImmGen Consortium
AU - Shay, Tal
AU - Jojic, Vladimir
AU - Zuk, Or
AU - Rothamel, Katherine
AU - Puyraimond-Zemmour, David
AU - Feng, Ting
AU - Wakamatsu, Ei
AU - Benoist, Christophe
AU - Koller, Daphne
AU - Regev, Aviv
PY - 2013/2/19
Y1 - 2013/2/19
N2 - Much of the knowledge about cell differentiation and function in the immune system has come from studies in mice, but the relevance to human immunology, diseases, and therapy has been challenged, perhaps more from anecdotal than comprehensive evidence. To this end, we compare two large compendia of transcriptional profiles of human and mouse immune cell types. Global transcription profiles are conserved between corresponding cell lineages. The expression patterns of most orthologous genes are conserved, particularly for lineage-specific genes. However, several hundred genes show clearly divergent expression across the examined cell lineages, and among them, 169 genes did so even with highly stringent criteria. Finally, regulatory mechanisms-reflected by regulators' differential expression or enriched cis-elements-are conserved between the species but to a lower degree, suggesting that distinct regulation may underlie some of the conserved transcriptional responses.
AB - Much of the knowledge about cell differentiation and function in the immune system has come from studies in mice, but the relevance to human immunology, diseases, and therapy has been challenged, perhaps more from anecdotal than comprehensive evidence. To this end, we compare two large compendia of transcriptional profiles of human and mouse immune cell types. Global transcription profiles are conserved between corresponding cell lineages. The expression patterns of most orthologous genes are conserved, particularly for lineage-specific genes. However, several hundred genes show clearly divergent expression across the examined cell lineages, and among them, 169 genes did so even with highly stringent criteria. Finally, regulatory mechanisms-reflected by regulators' differential expression or enriched cis-elements-are conserved between the species but to a lower degree, suggesting that distinct regulation may underlie some of the conserved transcriptional responses.
KW - Comparative transcriptomics
KW - Evolution
KW - Gene expression
KW - Microarray
UR - http://www.scopus.com/inward/record.url?scp=84874235143&partnerID=8YFLogxK
U2 - 10.1073/pnas.1222738110
DO - 10.1073/pnas.1222738110
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 23382184
AN - SCOPUS:84874235143
SN - 0027-8424
VL - 110
SP - 2946
EP - 2951
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 8
ER -