Conserved pleiotropy of an ancient plant homeobox gene uncovered by cis-regulatory dissection

Anat Hendelman, Sophia Zebell, Daniel Rodriguez-Leal, Noah Dukler, Gina Robitaille, Xuelin Wu, Jamie Kostyun, Lior Tal, Peipei Wang, Madelaine E. Bartlett, Yuval Eshed, Idan Efroni*, Zachary B. Lippman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Functional

Original languageAmerican English
Pages (from-to)1724-1739.e16
JournalCell
Volume184
Issue number7
DOIs
StatePublished - 1 Apr 2021

Bibliographical note

Funding Information:
We thank members of the Lippman laboratory for valuable comments and discussions. We thank J. Kim and A. Krainer for technical support. We thank L. Randall, A. Horowitz Doyle, P. Keen, K. Swartwood, M. Tjahjadi, and J. Van Eck for performing tomato and groundcherry transformations. We thank T. Mulligan, K. Schlecht, A. Krainer, and S. Qiao for assistance with plant care. We thank M. Karaca from Inari Agriculture for assistance with ATAC-seq (prior to September 2018). We thank B. Usadel, S. Strickler, and L. Mueller for sharing the S. lycopersicoides genome assembly and annotation sequences. We thank D. Jackson for comments on the manuscript. This research was supported by the Howard Hughes Medical Institute and grant support from the BARD (United States-Israel Binational Agricultural Research and Development Fund, IS-5120-18C ) to Y.E. and Z.B.L. and the Vaadia-BARD Postdoctoral Fellowship (award no. FL-542-16 ) to A.H., the Howard Hughes Medical Institute International Scholar Grant ( 55008730 ) and Israel Science Foundation ( ISF966/17 ) to I.E., and the National Science Foundation Plant Genome Research Program (grant no. IOS-1546837 ) to M.E.B. and Z.B.L.

Funding Information:
We thank members of the Lippman laboratory for valuable comments and discussions. We thank J. Kim and A. Krainer for technical support. We thank L. Randall, A. Horowitz Doyle, P. Keen, K. Swartwood, M. Tjahjadi, and J. Van Eck for performing tomato and groundcherry transformations. We thank T. Mulligan, K. Schlecht, A. Krainer, and S. Qiao for assistance with plant care. We thank M. Karaca from Inari Agriculture for assistance with ATAC-seq (prior to September 2018). We thank B. Usadel, S. Strickler, and L. Mueller for sharing the S. lycopersicoides genome assembly and annotation sequences. We thank D. Jackson for comments on the manuscript. This research was supported by the Howard Hughes Medical Institute and grant support from the BARD (United States-Israel Binational Agricultural Research and Development Fund, IS-5120-18C) to Y.E. and Z.B.L. and the Vaadia-BARD Postdoctoral Fellowship (award no. FL-542-16) to A.H. the Howard Hughes Medical Institute International Scholar Grant (55008730) and Israel Science Foundation (ISF966/17) to I.E. and the National Science Foundation Plant Genome Research Program (grant no. IOS-1546837) to M.E.B. and Z.B.L. Z.B.L. conceived the project. A.H. S.Z. D.R.-L. X.W. I.E. and Z.B.L. designed and planned experiments. A.H. S.Z. D.R.-L. G.R. X.W. L.T. P.W. Y.E. I.E. and Z.B.L. performed experiments and collected data. A.H. S.Z. N.D. X.W. J.K. P.W. M.E.B. I.E. and Z.B.L. analyzed data and A.H. I.E. and Z.B.L. wrote the manuscript with input from M.E.B. and Y.E. All authors read, edited, and approved the manuscript. Z.B.L. is a consultant for and a member of the Scientific Strategy Board of Inari Agriculture, and he is also a named inventor on a number of patents and patent applications directed to related technology that have been exclusively licensed from CSHL to Inari Agriculture.

Publisher Copyright:
© 2021 Elsevier Inc.

Keywords

  • ATAC sequencing
  • Arabidopsis
  • Brassicaceae
  • Solanaceae
  • cis-regulatory
  • conserved non-coding sequences
  • homeobox
  • inflorescence
  • plant development
  • pleiotropy
  • tomato

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