Constituents, Antibacterial Adhesion, Cytotoxic and in Vitro Metastasis Blocking Properties of Salvia fruticosa Essential Oils from Three Palestinian Localities

Nidal Jaradat*, Samer Abdallah, Nawaf Al-Maharik, Mohammad Altamimi, Mohammed Hawash, Mohammad Qneibi, Abeer Abu Khair, Anaal Zetawi, Leena Jabarin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Essential oils (EOs) of Salvia fruticosa Mill. gathered from three Palestinian localities were studied to determine their constituents, antibacterial adhesion impact against Klebsiella pneumonia, cytotoxicity, and their function in cancer cell migration. Gas chromatography-mass spectrometry identified the chemical components, while the MTT technique was used to measure the EOs′ cytotoxicity against HeLa (cervical) and Caco-2 (colorectal) cancer cells. Antibacterial adhesion was assessed by examining Klebsiella pneumoniae’s ability to adhere to Caco-2 cells. Our study found that eucalyptol was present as the main constituent in all S. fruticosa EOs. In addition, K. pneumoniae adhesion and metastasis were reduced after 48 h of application. Salfit's and Hebron's EOs had the most potent cytotoxic effects on Caco-2 and HeLa, with IC50 values in the range of 0.7–1.3 μg/mL. Taking into account the obtained results, it may be concluded that S. fruticosa EOs can serve as potential disinfectant agents for the treatment and prevention of K. pneumoniae-associated illness and cancer.

Original languageAmerican English
Article numbere202100872
JournalChemistry and Biodiversity
Volume19
Issue number4
Early online date15 Feb 2022
DOIs
StatePublished - Apr 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 Wiley-VHCA AG, Zurich, Switzerland.

Keywords

  • Bacterial anti-adhesion
  • Salvia fruticosa
  • cancer cell migration
  • cytotoxicity
  • essential oil
  • Caco-2 Cells
  • Anti-Bacterial Agents/chemistry
  • Humans
  • Arabs
  • Salvia/chemistry
  • Microbial Sensitivity Tests
  • Antineoplastic Agents/pharmacology
  • Oils, Volatile/chemistry
  • Klebsiella pneumoniae

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