Constitutive hyperhistaminaemia: A possible mechanism for recurrent anaphylaxis

A. Y. Hershko, Z. Dranitzki, R. Ulmanski, F. Levi-Schaffer, Y. Naparstek*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The process underlying anaphylaxis involves an uncontrolled elevation in blood levels of mediators, including histamine. Usually, these abnormal levels are attributed to the degranulation of basophils and mast cells. Few reports have assessed the contribution of defects in histamine pharmacodynamics to allergic responses. In this report we describe a patient with recurrent anaphylaxis who was initially suspected to have enhanced histamine intolerance. We evaluated urine and blood samples collected from this patient and from control individuals using an ELISA test. Our data clearly show constitutive hyperhistaminaemia and a markedly impaired urinary histamine clearance ratio in the index patient. It is suggested that this defect facilitates anaphylaxis.

Original languageAmerican English
Pages (from-to)449-452
Number of pages4
JournalScandinavian Journal of Clinical and Laboratory Investigation
Issue number6
StatePublished - 2001
Externally publishedYes


  • Anaphylaxis
  • Clearance
  • Histamine


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