Constructing realistic engrams: Poststimulus activity of hippocampus and dorsal striatum predicts subsequent episodic memory

Aya Ben-Yakov*, Yadin Dudai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

141 Scopus citations

Abstract

Encoding of real-life episodic memory commonly involves integration of information as the episode unfolds. Offline processing immediately following event offset is expected to play a role in encoding the episode into memory. In this study, we examined whether distinct human brain activitytime-lockedtotheoffsetofshortnarrativeaudiovisualepisodes could predict subsequent memory for the gist of the episodes. We found that a set of brain regions, most prominently the bilateral hippocampus and the bilateral caudate nucleus, exhibit memory-predictive activity time-locked to the stimulus offset. We propose that offline activity in these regions reflects registration to memory of integrated episodes.

Original languageAmerican English
Pages (from-to)9032-9042
Number of pages11
JournalJournal of Neuroscience
Volume31
Issue number24
DOIs
StatePublished - 15 Jun 2011
Externally publishedYes

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