Construction of Enantiopure Taxoid and Natural Product-like Scaffolds Using a C-C Bond Cleavage/Arylation Reaction

Manuel Weber; Kyle Owens; Ahmad Masarwa; Richmond Sarpong

doi:10.1021/acs.orglett.5b02797

Construction of Enantiopure Taxoid and Natural Product-like Scaffolds Using a C-C Bond Cleavage/Arylation Reaction

Manuel Weber
, Kyle Owens
, Ahmad Masarwa^*
, Richmond Sarpong

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

An approach to construct enantiopure complex natural product-like frameworks, including the first reported synthesis of a C17 oxygenated taxoid scaffold, is presented. A palladium-catalyzed C-C activation/cross-coupling is utilized to access these structures in a short sequence from (+)-carvone; the scope of this reaction is explored.

Original language	English
Pages (from-to)	5432-5435
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	21
DOIs	https://doi.org/10.1021/acs.orglett.5b02797
State	Published - 6 Nov 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

Access to Document

10.1021/acs.orglett.5b02797

Cite this

@article{84fad0a88f2d40479a8dbd843eb40784,

title = "Construction of Enantiopure Taxoid and Natural Product-like Scaffolds Using a C-C Bond Cleavage/Arylation Reaction",

abstract = "An approach to construct enantiopure complex natural product-like frameworks, including the first reported synthesis of a C17 oxygenated taxoid scaffold, is presented. A palladium-catalyzed C-C activation/cross-coupling is utilized to access these structures in a short sequence from (+)-carvone; the scope of this reaction is explored.",

author = "Manuel Weber and Kyle Owens and Ahmad Masarwa and Richmond Sarpong",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

month = nov,

day = "6",

doi = "10.1021/acs.orglett.5b02797",

language = "אנגלית",

volume = "17",

pages = "5432--5435",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "21",

}

TY - JOUR

T1 - Construction of Enantiopure Taxoid and Natural Product-like Scaffolds Using a C-C Bond Cleavage/Arylation Reaction

AU - Weber, Manuel

AU - Owens, Kyle

AU - Masarwa, Ahmad

AU - Sarpong, Richmond

PY - 2015/11/6

Y1 - 2015/11/6

N2 - An approach to construct enantiopure complex natural product-like frameworks, including the first reported synthesis of a C17 oxygenated taxoid scaffold, is presented. A palladium-catalyzed C-C activation/cross-coupling is utilized to access these structures in a short sequence from (+)-carvone; the scope of this reaction is explored.

AB - An approach to construct enantiopure complex natural product-like frameworks, including the first reported synthesis of a C17 oxygenated taxoid scaffold, is presented. A palladium-catalyzed C-C activation/cross-coupling is utilized to access these structures in a short sequence from (+)-carvone; the scope of this reaction is explored.

UR - https://www.scopus.com/pages/publications/84946781054

U2 - 10.1021/acs.orglett.5b02797

DO - 10.1021/acs.orglett.5b02797

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 26485318

AN - SCOPUS:84946781054

SN - 1523-7060

VL - 17

SP - 5432

EP - 5435

JO - Organic Letters

JF - Organic Letters

IS - 21

ER -

Construction of Enantiopure Taxoid and Natural Product-like Scaffolds Using a C-C Bond Cleavage/Arylation Reaction

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this