Abstract
Stimulus-specific adaptation (SSA) is the reduction in responses to frequent stimuli (standards) that does not generalize to rare stimuli (deviants). We investigated the contribution of inhibition in auditory cortex to SSA using two-photon targeted cell-attached recordings and optogenetic manipulations in male mice. We characterized the responses of parvalbumin (PV)-, somatostatin (SST)-, and vasoactive intestinal polypeptide (VIP)-expressing interneurons of layer 2/3, and of serotonin receptor 5HT3a-expressing interneurons of layer 1. All populations showed early-onset SSA. Unexpectedly, the PV, SST, and VIP populations exhibited a substantial late component of evoked activity, often stronger for standard than for deviant stimuli. Optogenetic suppression of PV neurons facilitated pyramidal neuron responses substantially more (approximately 310) for deviants than for standards. VIP suppression decreased responses of putative PV neurons, specifically for standard but not for deviant stimuli. Thus, the inhibitory network does not generate cortical SSA, but powerfully controls its expression by differentially affecting the responses to deviants and to standards.
| Original language | American English |
|---|---|
| Pages (from-to) | 4629-4651 |
| Number of pages | 23 |
| Journal | Journal of Neuroscience |
| Volume | 42 |
| Issue number | 23 |
| DOIs | |
| State | Published - 8 Jun 2022 |
Bibliographical note
Funding Information:T.S.Y. was supported by the Israeli President Scholarship for Excellence and Innovation in Brain Research and by the Gatsby Charitable Foundation. A.M. was supported by European Research Council (ERC) consolidator grant (616063) and a personal grant of the Israeli Science Foundation (224/17). I.N. was supported by personal grants of the Israel Science Foundation (390/2013 and 1126/2018), by a United States-Israel Binational Science Foundation–National Science Foundation grant (2016-688), and by an advanced ERC grant (340063). A.M. holds the Eric Roland Chair in Brain Sciences. I.N. holds the Milton and Brindell Gottlieb chair in Brain Sciences. We thank the following people for their technical support, advice, and discussions: Dr. Mickey London, Dr. Inbal Goshen, Dr. Lior Cohen, Dr. Yishai Elyada, Dr. Gen-ichi Tasaka, Dr. Ido Maor, Dr. Avi M. Libster, Dr. Itai Hershenhoren, Dr. Dina Moshitch, Dr. Maciej M. Jankowski, Dr. Johannes Niediek, Dr. Elena Kudryavitskaya, Dr. Amit Vinograd, Dr. Yasmin Yarden-Rabinowitz, Amos Shalev, Vitaly Lerner, Dr. Adi Kol, Alex Kazakov, Ana Polterovich, Mor Harpaz, Omer Amsalem, Omri Gilday, and Haran Shani-Narkiss. We also thank Dr. Ashlan Reid from Cold Spring Harbor Laboratory for providing us the Arch construct, and Dr. Maya Sherman from The Edmond and Lily Safra Center for Brain Sciences Vector Core Facility for designing and producing the viruses used in this study.
Funding Information:
T.S.Y. was supported by the Israeli President Scholarship for Excellence and Innovation in Brain Research and by the Gatsby Charitable Foundation. A.M. was supported by European Research Council (ERC) consolidator grant (616063) and a personal grant of the Israeli Science Foundation (224/17). I.N. was supported by personal grants of the Israel Science Foundation (390/2013 and 1126/2018), by a United States-Israel Binational Science Foundation–National Science Foundation grant (2016-688), and by an advanced ERC grant (340063). A.M. holds the Eric Roland Chair in Brain Sciences. I.N. holds the Milton and Brindell Gottlieb chair in Brain Sciences. We thank the following people for their technical support, advice, and discussions: Dr. Mickey London, Dr. Inbal Goshen, Dr. Lior Cohen, Dr. Yishai Elyada, Dr. Gen-ichi Tasaka, Dr. Ido Maor, Dr. Avi M. Libster, Dr. Itai Hershenhoren, Dr. Dina Moshitch, Dr. Maciej M. Jankowski, Dr. Johannes Niediek, Dr. Elena Kudryavitskaya, Dr. Amit Vinograd, Dr. Yasmin Yarden-Rabinowitz, Amos Shalev, Vitaly Lerner, Dr. Adi Kol, Alex Kazakov, Ana Polterovich, Mor Harpaz, Omer Amsalem, Omri Gilday, and Haran Shani-Narkiss. We also thank Dr. Ashlan Reid from Cold Spring Harbor Laboratory for providing us the Arch construct, and Dr. Maya Sherman from The Edmond and Lily Safra Center for Brain Sciences Vector Core Facility for designing and producing the viruses used in this study. The authors declare no competing financial interests.
Publisher Copyright:
Copyright © 2022 the authors
Keywords
- auditory cortex
- electrophysiology
- interneurons
- mouse
- optogenetics