Context-Dependent Inhibitory Control of Stimulus-Specific Adaptation

Tohar S. Yarden, Adi Mizrahi, Israel Nelken*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Stimulus-specific adaptation (SSA) is the reduction in responses to frequent stimuli (standards) that does not generalize to rare stimuli (deviants). We investigated the contribution of inhibition in auditory cortex to SSA using two-photon targeted cell-attached recordings and optogenetic manipulations in male mice. We characterized the responses of parvalbumin (PV)-, somatostatin (SST)-, and vasoactive intestinal polypeptide (VIP)-expressing interneurons of layer 2/3, and of serotonin receptor 5HT3a-expressing interneurons of layer 1. All populations showed early-onset SSA. Unexpectedly, the PV, SST, and VIP populations exhibited a substantial late component of evoked activity, often stronger for standard than for deviant stimuli. Optogenetic suppression of PV neurons facilitated pyramidal neuron responses substantially more (approximately 310) for deviants than for standards. VIP suppression decreased responses of putative PV neurons, specifically for standard but not for deviant stimuli. Thus, the inhibitory network does not generate cortical SSA, but powerfully controls its expression by differentially affecting the responses to deviants and to standards.

Original languageAmerican English
Pages (from-to)4629-4651
Number of pages23
JournalJournal of Neuroscience
Volume42
Issue number23
DOIs
StatePublished - 8 Jun 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 the authors

Keywords

  • auditory cortex
  • electrophysiology
  • interneurons
  • mouse
  • optogenetics

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