Context-dependent regulation of Groucho/TLE-mediated repression

Einat Cinnamon*, Ze'ev Paroush

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations

Abstract

Groucho/TLE proteins are global corepressors that are recruited to target promoters by different families of DNA-binding repressors. As these corepressors are widely expressed, the long-standing view had been that Groucho/TLE-mediated repression is regulated solely by the spatial and temporal distribution of partner repressors. It has recently emerged, however, that Groucho/TLE repressor activity is itself regulated, in a signal induced, context-dependent manner. Here we review the essential roles played by Groucho/TLE factors in different cell-signalling processes that illustrate different modes for regulating Groucho/TLE-mediated repression: (i) via the expression of partner repressors; (ii) by competition with coactivators and (iii) through post-translational modifications of Groucho/TLE. We also discuss how the intrinsic properties of repressors can result in differential responses to Groucho/TLE regulation.

Original languageAmerican English
Pages (from-to)435-440
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume18
Issue number5
DOIs
StatePublished - Oct 2008

Bibliographical note

Funding Information:
We thank Peleg Hasson, Gerardo Jiménez, Amir Orian and Joel Yisraeli for their valuable comments on the manuscript, particularly Gerardo Jiménez for many fruitful and enjoyable discussions. We apologise to our many colleagues for the incomplete referencing due to rigid space constraints. Work in our laboratory is supported by grants from the Israel Science Foundation (501/04 and the FIRST/Bikura Programme), Israel Cancer Research Fund, German-Israeli Foundation (905-14.13/2006) and the Król Charitable Foundation. EC is an EMBO long-term postdoctoral fellow and ZP a Braun lecturer in medicine.

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